Table I.
Baseline characteristics of the studies included.
| First author | Region | Year | Sample | Histology | Studya | Follow-up (years) | Mean age (years) | Surgeryb | RAI | Quality score | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pellegriti | Italy | 2004 | 299 | PTC | R | 3.8 | 41.9 | nTT,TT | 30.40% | 9 | (18) |
| Barbaro | Italy | 2005 | 91 | PTC | R | None | No detail | TT | No detail | 7 | (19) |
| Reddy | USA | 2006 | 551 | DTC | R | 3.6 | No detail | TT or sTT | No detail | 7 | (20) |
| Bilimoria | USA | 2007 | 28,016 | PTC | R | 5.8 | 43 | TT,lobectomy | 51.30% | 7 | (8) |
| Rossi | Italy | 2008 | 426 | DTC | R | 5.4 | 53 | nTT,TT | 95.80% | 9 | (14) |
| Krämer | Germany Austria | 2010 | 221 | DTC | P | 6.3 | 47.7 | TT | all | 8 | (21) |
| Ito | Japan | 2010 | 2,638 | PTC | R | 7.6 | 51.1 | TT, sTT, lobectomy | 0.10% | 8 | (17) |
| Nixon | USA | 2011 | 707 | DTC | R | 8.2 | No detail | TT,sTT, lobectomy | 26% | 7 | (22) |
| Ibrahimpasic | USA | 2012 | 200 | PTC | R | 5.2 | No detail | TT | 40.1% | 8 | (23) |
| Avram | USA | 2013 | 116 | DTC | R | None | 47 | TT, lobectomy | 3.40% | 9 | (24) |
| Momesso | Brazil | 2014 | 176 | DTC | R | 14.1 | 40.2 | TT+sTT | 57.3% | 9 | (26) |
| Han | Korea | 2014 | 176 | DTC | R | 7.2 | 50.1 | TT | all | 8 | (27) |
| Wang | USA | 2014 | 1,522 | DTC | R | 3.8 | 48 | TT,sTT, lobectomy | 6% | 9 | (13) |
| Smith | England | 2015 | 35 | PTC | R | 6 | No detail | TT, lobectomy | 51.40% | 6 | (25) |
| Baek | Korea | 2015 | 659 | PTC | R | None | 45.9 | TT,sTT, lobectomy | No detail | 9 | (28) |
| Nilubol | USA | 2015 | 30,184 | PTC | R | 4.5 | No detail | TT,sTT, lobectomy | 47.10% | 8 | (5) |
| Vrachimis | Germany | 2015 | 221 | DTC | R | 7.8 | 47,7 | TT | all | 8 | (6) |
| Chereau | France | 2016 | 2,518 | PTC | R | 6.5 | 50 | TT, lobectomy | 49.60% | 9 | (12) |
| Anderson | USA | 2016 | 149,912 | DTC | R | None | 50.6 | TT, lobectomy | 37.60% | 9 | (7) |
| Sun | China | 2017 | 269 | DTC | R | None | No detail | TT,lobectomy | No detail | 7 | (29) |
| Aydin Buyruk | Turkey | 2017 | 354 | PTC | R | None | No detail | TT | No detail | 8 | (30) |
a
Study design
b
surgery; P, prospective study; R, respective study; TT, total thyroidectomy; sTT, subtotal thyroidectomy; nTT, near total thyroidectomy.