Table 3.
Associations of baseline cognition with other biomarkers (18F-AV45-PET, 18F-FDG-PET, MRI, CSF) at baseline.
| Baseline cognition | AV45 |
FDG |
MRI |
CSF |
||
|---|---|---|---|---|---|---|
| Cortical SUVRCB | Cortical SUVRWM | PCC SUVR | HV | Aβ1–42 | Aβ1–42/P-tau181 | |
| MMSE | −0.21 (0.099) | −0.15 (0.235) | +0.34 (0.004) | +0.16 (0.258) | −0.03 (0.866) | +0.10 (0.433) |
| Delayed memory | −0.23 (0.017) | −0.26 (0.005) | +0.33 (<0.001) | +0.38 (<0.001) | +0.32 (0.005) | +0.25 (0.019) |
| List recall | −0.29 (0.004) | −0.23 (0.016) | +0.27 (0.004) | +0.28 (0.010) | +0.24 (0.026) | +0.13 (0.188) |
| Story recall | −0.34 (0.002) | −0.25 (0.022) | +0.12 (0.255) | +0.21 (0.100) | +0.23 (0.070) | +0.12 (0.328) |
| Figure recall | −0.36 (0.002) | −0.40 (<0.001) | +0.32 (0.004) | +0.33 (0.011) | +0.36 (0.008) | +0.40 (0.001) |
| Immediate memory | −0.29 (0.002) | −0.34 (<0.001) | +0.19 (0.042) | +0.11 (0.310) | +0.20 (0.084) | +0.16 (0.125) |
| Language | −0.15 (0.258) | −0.13 (0.319) | +0.02 (0.872) | −0.11 (0.459) | +0.23 (0.105) | +0.21 (0.103) |
| Visuospatial construction | −0.31 (0.038) | −0.18 (0.221) | +0.20 (0.163) | +0.37 (0.022) | −0.02 (0.889) | −0.12 (0.455) |
Standardized regression coefficients β (and p-values) were retrieved from linear regression adjusted for age, sex, APOE ε4, education, and baseline clinical diagnosis. Significant associations that survived FDR-correction are shown in bold typeface. All biomarkers that only showed non-significant associations were omitted from the Table.
Abbreviations: CSF cerebrospinal fluid, HV hippocampal volume, MMSE Mini-Mental state examination, MRI magnetic resonance imaging, PCC posterior cingulate cortex, PET positron emission tomography, P-tau181 phosphorylated tau181, SUVRCB standardized uptake value ratio normalized to cerebellar grey matter, SUVRWM standardized uptake value ratio normalized to subcortical white matter.