Table 4.
Associations of 1-year cognitive decline (Δ) with other biomarkers (18F-FDG-PET, MRI) at baseline.
| Δcognition | FDG |
MRI |
|---|---|---|
| PCC SUVR | HV | |
| ΔMMSE | +0.19 (0.286) | +0.47 (0.010) |
| ΔDelayed memory | +0.55 (0.003) | +0.46 (0.044) |
| ΔList recall | +0.31 (0.020) | +0.27 (0.076) |
| ΔStory recall | +0.43 (<0.001) | +0.37 (0.005) |
| ΔFigure recall | +0.37 (0.008) | +0.31 (0.052) |
| ΔImmediate memory | +0.26 (0.120) | +0.14 (0.439) |
| ΔLanguage | +0.08 (0.563) | +0.36 (0.019) |
| ΔVisuospatial construction | +0.09 (0.601) | −0.07 (0.711) |
Standardized regression coefficients β (and p-values) were retrieved from linear regression adjusted for age, sex, APOE ε4, education, baseline clinical diagnosis, baseline cognition, and cognition interval. Significant associations that survived FDR-correction are shown in bold typeface. All biomarkers that only showed non-significant associations were omitted from the Table
Δcognition = ZFU – ZBL.
Abbreviations: HV hippocampal volume, MMSE Mini-Mental state examination, MRI magnetic resonance imaging, PCC posterior cingulate cortex, SUVR standardized uptake value ratio.