Table 5.
Difference in the rate of cognitive change over 2 years between positive and negative 18F-FDG-, 18F-AV45-, or MRI-groups at baseline.
| FDG |
AV45 |
MRI |
|||
|---|---|---|---|---|---|
| Read |
Quantitative |
Read |
Read |
||
| SUVRCB | SUVRWM | ||||
| MMSE | +0.42 (<0.001) | +0.33 (0.004) | +0.34 (0.005) | +0.27 (0.011) | +0.27 (0.012) |
| Delayed memory | +0.17 (0.014) | +0.14 (0.024) | +0.16 (0.011) | +0.19 (0.001) | +0.14 (0.022) |
| List recall | +0.12 (0.222) | +0.24 (0.004) | +0.31 (<0.001) | +0.21 (0.012) | +0.12 (0.172) |
| Story recall | +0.06 (0.589) | +0.15 (0.093) | +0.02 (0.801) | +0.12 (0.197) | +0.23 (0.012) |
| Figure recall | +0.09 (0.388) | +0.11 (0.231) | +0.14 (0.137) | +0.02 (0.820) | +0.06 (0.542) |
| Immediate memory | +0.19 (0.058) | +0.17 (0.051) | +0.16 (0.079) | +0.11 (0.233) | +0.18 (0.040) |
| Language | +0.27 (0.013) | −0.006 (0.954) | −0.02 (0.883) | −0.01 (0.900) | +0.26 (0.009) |
| Visuospatial construction | +0.01 (0.925) | +0.10 (0.456) | +0.03 (0.794) | +0.08 (0.509) | +0.11 (0.373) |
Standardized regression coefficients β (and p-values) were retrieved from linear mixed model analysis, adjusted for the covariates. Values in bold typeface represent a significant time-by-status interaction that survived FDR-correction, i.e. a significant faster cognitive decline in the biomarker positive versus negative group at baseline.
18F-FDG and MRI dichotomization (positive or negative) was based on visual reading, whereas 18F-AV45 dichotomization was based on either visual reading or a quantitative cut-off (SUVRCB or SUVRWM). The CSF Aβ1–42/Aβ1–40 and Aβ1–42/T-tau ratios were omitted from the Table, as there were no significant interactions.
Abbreviations: MMSE Mini-Mental state examination, MRI magnetic resonance imaging, SUVRCB standardized uptake value ratio normalized to cerebellar grey matter, SUVRWM standardized uptake value ratio normalized to subcortical white matter.