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. 2018 Dec 27;7(3):655–678. doi: 10.1016/j.jcmgh.2018.12.007

Figure 5.

Figure 5

Histopathology of colon at E18.5 and P4. (A and B) Representative H&E-stained coronal sections of the colon at E18.5. No gross difference was observed between genotypes (N = 3–4 animals per genotype). (C and D). H&E staining from WT and Gfra1hypo/hypo colon at P4. Gfra1hypo/hypo animals typically show mild crypt dilatation accompanied with mucus retention (D2, black bold arrow). AB-PAS staining shows more acidic mucins in WT animals at the basal crypts (C3, open arrowhead) and more neutral mucins in Gfra1hypo/hypo animals (white arrowheads) quantified in F. **P < .01 (N = 3–4). (E) The number of goblet cells (C3 and D3, white arrows) was not changed at P4 (N = 4–5). Analysis of variance and the Tukey multiple comparisons test, data are presented as means ± SEM. All summary data are presented as means ± SEM.