Table 2.
Summary of Histopathologic Findings at P4
| P4 | ID | Weight, g | Sex | Applied Teitelbaum et al7 grade | Surface epithelial injury | Crypt dilation | Intraepithelial apoptotic remnants | Goblet cell hyperplasia | Mucins in crypts |
Bacteria in crypts | Enterocyte adherence | Leukocytes |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mucin shift to PAS | Basal | Surface | Mucus retention | Granulocytes | Lymphocytes | |||||||||||
| WT | 7615-2 | 3.02 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 7640-3 | 2.96 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 7640-4 | 3.16 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 7640-4a | 2.92 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT/hypo | 7615-4 | 3.15 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | + |
| WT/hypo | 7615-1 | 3.21 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT/hypo | 7615-5 | 3.06 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT/hypo | 7640-5a | 2.78 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| Hypo/hypo | 7615-3 | 2.60 | F | I | Mild | ++ | - | No | Yes | PAS | PAS | ++ | - | No | - | - |
| Hypo/hypo | 7640-1 | 2.38 | F | I | Mild | ++ | - | No | Yes | PAS | PAS | ++ | - | No | - | - |
| Hypo/hypo | 7640-1a | 2.34 | M | I | Mild | +++ | - | No | Yes | PAS | PAS | ++ | - | No | - | - |
| Hypo/hypo | 7640-3a | 2.44 | M | I | Minimal | + | - | No | Yes | PAS | PAS | ++ | - | No | - | - |
| Hypo/hypo | 7640-2 | 2.51 | M | II | Moderate | ++ | + | No | Yes | PAS | PAS | ++ | - | No | - | - |
| Minimal | Mild + | Mild + | Mild + | Mild + | Normal - (<4/HPF) | |||||||||||
| 0–V | Mild | Moderate ++ | Moderate ++ | Yes/no | Yes/no | Moderate ++ | Moderate ++ | Yes/no | Mild + (5–15/HPF) | |||||||
| Moderate | Marked +++ | Marked +++ | Marked +++ | Moderate ++ (20–30/HPF) | ||||||||||||
| Marked | ||||||||||||||||
NOTE. See the Materials and Methods section for details regarding the histopathologic grading.