Table 3.
Summary of Histopathologic Findings at P10
| P10 | ID | Weight, g | Sex | Applied Teitelbaum et al7 grade | Surface epithelial damage | Crypt dilation | Intraepithelial apoptotic remnants | Goblet cell hyperplasia | Mucins in crypts |
Bacteria in crypts | Enterocyte adherence | Leukocytes |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mucin shift to PAS | Basal | Surface | Mucus retention | Granulocytes | Lymphocytes | |||||||||||
| WT | 10 | 6.8 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 23 | 5.3 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 6280-1 | 8 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT | 31 | 4.12 | M | 0 | - | - | - | No | No | AB/PAS | PAS | - | - | No | - | - |
| WT/hypo | 22 | 6.09 | M | 0 | - | - | - | No | No | AB/PAS | PAS | - | - | No | - | - |
| WT/hypo | 24 | 6.42 | F | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | -/+ |
| WT/hypo | 6777-3 | 5.18 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT/hypo | 6280-2 | 7.84 | M | 0 | - | - | - | No | No | AB | PAS | - | - | No | - | - |
| WT/hypo | 12 | 6.42 | M | 0-I | No/minimal | - | - | No | No | AB/PAS | PAS | - | - | No | - | - |
| Hypo/hypo | 11 | 3.61 | M | I | Minimal | - | - | Yes | Yes | PAS | PAS | - | - | No | - | - |
| Hypo/hypo | 27 | 7.57 | M | II | Mild | - | + | Yes | Yes | PAS | PAS | - | - | No | - | - |
| Hypo/hypo | 6277-7 | 3.6 | F | II | Mild | +/++ | - | Yes | Yes | PAS | PAS | + | - | No | - | - |
| Hypo/hypo | 21 | 4.93 | F | III | Moderate | + | + | Yes | Yes | PAS | PAS | ++ | - | No | - | + |
| Hypo/hypo | 6224-2 | 4.15 | M | II | Mild | + | + | Yes | Yes | PAS | PAS + AB | + | - | No | - | - |
| Hypo/hypo | 6224-7 | 5.93 | F | III | Moderate | ++ | + | Yes | Yes | PAS | PAS + AB | + | - | No | ++ | - |
| Hypo/hypo | 7310-1 | 4.53 | M | III | Moderate | ++ | + | Yes | Yes | PAS/ foamyAB | PAS/ foamyAB | ++ | - | No | - | - |
| Hypo/hypo | 7310-2 | 3.62 | M | II | Mild | ++/+++ | - | Yes | Yes | PAS/ foamyAB | PAS/ foamyAB | ++ | - | No | - | - |
| Minimal | Mild + | Mild + | Mild + | Mild + | Normal - (<4/HPF) | |||||||||||
| 0–V | Mild | Moderate ++ | Moderate ++ | Yes/no | Yes/no | Moderate ++ | Moderate ++ | Yes/no | Mild + (5–15/HPF) | |||||||
| Moderate | Marked +++ | Marked +++ | Marked +++ | Moderate ++ (20–30/HPF) | ||||||||||||
| Marked | ||||||||||||||||
NOTE. See the Materials and Methods section for details regarding the histopathologic grading.