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. 2019 Mar 26;13:117. doi: 10.3389/fncel.2019.00117

FIGURE 2.

FIGURE 2

Influence of SEMA3A on neurological outcomes following TBI. (A) Schematic diagram of the experimental design. (B,C) The expression of SEMA3A was blocked by siRNA-SEMA3A in vivo. (D,E) We used mNSSs to test neurological function (D) and beam balance tests (E) to evaluate motor function on the 1st, 3rd, 7th, and 14th days post-CCI. The downregulation of SEMA3A significantly decreased mNSS scores and reduced the times on the beam balance test on the third day after injury. The data are expressed as the mean ± SEM, and n = 6 for each group. #p < 0.01 vs. control groups, ∗p < 0.05 TBI+siRNA-SEMA groups vs. siRNA-control groups, ∗∗p < 0.05 TBI+SEMA3A groups vs. TBI+PBS groups.