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. 2019 Feb 28;17(5):4263–4270. doi: 10.3892/ol.2019.10082

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Copyright: © Cheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Downregulation of ISOC1 inhibits the proliferation of pancreatic cancer cells. (A) Fluorescent microscopic images of SW 1990 and PANC-1 cells infected with shCtrl or shISOC1 lentivirus during days 1–5. (B) Cell growth curve of SW 1990 and PANC-1 cells following ISOC1 knockdown. Cell number was monitored with a Celigo assay. (C) Cell number fold curve of SW 1990 and PANC-1 cells after ISOC1 knockdown. (D) Cell growth curve of SW 1990 and PANC-1 cells following ISOC1 knockdown. Cell viability was monitored with an MTT assay through OD490. (E) Curve of OD490 fold of SW 1990 and PANC-1 cells following ISOC1 knockdown. Scale bars, 100 µm. ***P<0.001, comparing the shCtrl and shISOC1 groups. ISOC1, isochorismatase domain-containing protein 1; shCtrl, control short hairpin RNA; OD, optical density.

Figure 3. — Downregulation of ISOC1 inhibits the proliferation of pancreatic cancer cells. (A) Fluorescent microscopic images of SW 1990 and PANC-1 cells infected with shCtrl or shISOC1 lentivirus during days 1–5. (B) Cell growth curve of SW 1990 and PANC-1 cells following ISOC1 knockdown. Cell number was monitored with a Celigo assay. (C) Cell number fold curve of SW 1990 and PANC-1 cells after ISOC1 knockdown. (D) Cell growth curve of SW 1990 and PANC-1 cells following ISOC1 knockdown. Cell viability was monitored with an MTT assay through OD490. (E) Curve of OD490 fold of SW 1990 and PANC-1 cells following ISOC1 knockdown. Scale bars, 100 µm. ***P<0.001, comparing the shCtrl and shISOC1 groups. ISOC1, isochorismatase domain-containing protein 1; shCtrl, control short hairpin RNA; OD, optical density.