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. 2019 Feb 28;17(5):4263–4270. doi: 10.3892/ol.2019.10082

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Copyright: © Cheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Depletion of ISOC1 promotes cell apoptosis. (A) Flow cytometry combined with Annexin V staining was used to analyze cell apoptosis in SW 1990 and PANC-1 knockdown. (B) Statistical analysis of apoptotic cell in SW1990 and PANC-1 with and without ISOC1 depletion. (C) Caspase 3/7 assay was used to determine the caspase 3/7 activity following ISOC1 knockdown. ***P<0.01, compared with the shCtrl group. ISOC1, isochorismatase domain-containing protein 1; shCtrl, control short hairpin RNA.