Table I.

Summary of the diagnostic reflectance confocal microscopy features for common skin cancers.

Type of skin cancer	Reflectance confocal microscopy features	Author, year (Refs.)
Basal cell carcinoma	Bright tumor islands/dark silhouettes	Caruntu et al, 2014 (33)
	Peritumoral clefting	Ghita et al, 2016 (31)
	Streaming of the epidermis	González and Tannous, 2002 (36)
	Prominent and tortuous blood vessels	Longo et al, 2014 (32)
	Inflammatory cells ± bright dendritic structures	Nori et al, 2004 (35)
	Spoke wheel-like structures	Peppelman et al, 2013 (34)
		Segura et al, 2007 (41)
		Stephens et al, 2013 (37)
		Ulrich et al, 2010 (38)
Squamous cell carcinoma	Hyperkeratois	Aghassi et al, 2000 (55)
	Disarranged honeycomb pattern with enlarged, pleomorphic nuclei in the spinous-granular layers	Branzan et al, 2006 (58)
		Peppelman et al, 2014 (56)
	Round, nucleated bright cells in the suprabasal epidermis	Que et al, 2015 (39)
	Elongated dermal papillae with looping, round vessels	Rishpon et al, 2009 (57)
Melanoma	Pagetoid spread of roundish or dendritic cells in the epidermis	Carrera et al, 2012 (80)
	Pleomorphic cells and atypical nests at the dermo-epidermal junction	Guida et al, 2015 (16)
		Pellacani et al, 2007 (15)
	Non-edged papillae and atypical nucleated cells in the papillary dermis	Pellacani et al, 2014 (17)
		Ulrich and Lange-Asschenfeldt, 2013 (79)
	Poorly defined or absent keratinocytes cell borders
Mycosis fungoides	Weakly refractile cells (lymphocytes), Vesicle-like spaces (Pautrier collections) within the epidermis	Agero et al, 2007 (90)
		Fabbrocini et al, 2017 (85)
	Hypo-refractile papillary rings and dilated capillaries	Koller et al, 2009 (89)
		Lange-Asschenfeldt et al, 2012 (88)
		Li et al, 2013 (87)
		Mancebo et al, 2016 (86)
Primary cutaneous folliculocentric lymphoma	Round-shaped, highly-refractive tumor masses	Unpublished study
	Bright cells of various sizes and numerous bright small cells (lymphocytes) at the periphery of tumor masses