Figure 8.

Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway. (A) Alterations in the expression levels of proteins involved in common signaling pathways in HCCML3 cells following treatment with polydatin at various concentrations, were evaluated by western blotting. (B) Statistical analysis of protein expression. All protein expression levels have been normalized to β-actin prior to further normalization with total protein level. *P<0.05, **P<0.01, ***P<0.001 vs. control. AKT, protein kinase B; FOXO1, forkhead box protein O1; ns, not significant; STAT3, signal transducer and activator of transcription 3.