Table 1.

Cytokines detected in dHACM extract by Human Cytokine 42-Plex Discovery Assay. For each protein, seven standard levels were described based on the lowest (1) to highest (7) concentration expected in the medium solution (parameter logistic standard curve [SC]). We defined low concentration as SC < 4 (SC 2 or 3), intermediate as SC = 4, and high as SC > 4 (SC 5, 6, or 7).

	Low	Intermediate	High
Growth factors	EGF, FGF-2, G-CSF, GROα, MCP-3, MDC, PDGF-AA	PDGF-BB	TGF-B1, TGF-B2, IP-10, MCP-1, MIP-1a, CCL5
Interleukins	IL-1a, IL-4, IL-6, IL-18	IL-15	IL-1RA, IL-8
MMP	MMP-12	–	MMP-2, MMP-8, MMP-9, MMP-10
TIMP	TIMP-4	–	TIMP-1

CCL5, chemokine ligand 5; EGF, epidermal growth factor; FGF, fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; GROα, growth-regulated protein alpha; IP-10, interferon gamma-induced protein 10; MCP, monocyte chemotactic protein; MDC, mediator of DNA damage checkpoint; MIP, macrophage inflammatory protein; MMP, matrix metalloproteinase; PDGF, platelet derived growth factors; TGF, transforming growth factor; TIMP, tissue inhibitor of metalloproteinases.