Figure 4.

Depletion of TNFAIP8 affects cellular apoptosis and the p38 mitogen-activated protein kinase signaling pathway. (A) Caspase-3 and caspase-8 activation in control HeLa cells or in TNFAIP8-silenced cells, in the presence or absence of cisplatin (5 µg/ml). (B) Expression levels of p38, p-p38, Bcl-2 and TNFAIP8 in TNFAIP8-silenced HeLa and control cells in the presence or absence of CDDP (5 µg/ml). Data are representative of three independent experiments. TNFAIP8, tumor necrosis factor α-induced protein 8; Scr, scrambled control RNA; CDDP, cisplatin; Bcl-2, B-cell lymphoma 2; p-, phosphorylated.