Table II.
Candidate marker proteins for cetuximab sensitivity.
| No. | MOWSE score | % Coverage | Protein name | Accession no. | Fraction | Marker |
|---|---|---|---|---|---|---|
| 1 | 7198 | 14.4 | L-lactate dehydrogenase B chain | P07195 | Cytoplasm | Cmab-R |
| 2 | 911 | 10.4 | Uncharacterized protein C18orf63 | Q68DL7 | Membrane | Cmab-S |
| 3 | 573 | 7.1 | Serine/threonine-protein kinase TAO1 | Q7L7X3 | Membrane | Cmab-S |
| 4 | 303 | 4 | Protein phosphatase Slingshot homolog 1 | Q8WYL5 | Membrane | Cmab-S |
| 5 | 273 | 4.9 | Coiled-coil domain-containing protein 110 | Q8TBZ0 | Cytoplasm | Cmab-S |
| 6 | 242 | 5.4 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 | O60231 | Membrane | Cmab-S |
| 7 | 240 | 4.6 | Exocyst complex component 6B | Q9Y2D4 | Membrane | Cmab-S |
| 8 | 237 | 7.9 | Zinc finger protein 771 | Q7L3S4 | Membrane | Cmab-R |
| 9 | 224 | 13.5 | Protein LIAT1 | Q6ZQX7 | Membrane | Cmab-S |
| 10 | 223 | 8.7 | Kelch-like protein 41 | O60662 | Membrane | Cmab-S |
MOWSE, molecular weight search; Cmab-S, cetuximab-sensitive group; Cmab-R, cetuximab-resistance group.