Table 2.
Clinical and biological parameters (mean ± SE) of 16 morbidly obese female subjects in basal state (basal (T0)) and 3, 6 and 12 months after surgical induced weight loss
| Basal (T0) | Weight loss follow-up |
|||
|---|---|---|---|---|
| 3 months | 6 months | 12 months | ||
| Adipocyte mean size, µm | 93.1 ± 3.2 | 82.3 ± 5.5a | – | – |
| ATM, % | 18.8 ± 3.7 | 14.1 ± 3.3a | – | – |
| Glucose homeostasis | ||||
| BMI, kg/m2 | 47.2 ± 1.8 | 39.9 ± 1.3a | 37.7 ± 1.5a | 33.6 ± 1.3a |
| Glucose, mmol/l | 5.54 ± 0.4 | 5.2 ± 0.02a | 5.1 ± 0.03a | 4.8 ± 0.02a |
| Insulin, µU/ml | 11.7 ± 2.3 | 6.6 ± 0.76a | 5.8 ± 0.57a | 4.5 ± 0.59a |
| Lipid homeostasis | ||||
| Cholesterol, mmol/l | 5.2 ± 0.2 | 4.9 ± 0.2 | 5.2 ± 0.2 | 5.01 ± 0.2 |
| HDL-cholesterol, mmol/l | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.4 ± 0.1 | 1.7 ± 0.1a |
| Triglycerides, mmol/l | 1.3 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | 0.9 ± 0.1a |
| Adipokines | ||||
| Leptin, ng/ml | 64.5 ± 6.6 | 36.1 ± 3.9a | 29.9 ± 3.8a | 26.3 ± 3.4a |
| Adiponectin, µg/ml | 7.6 ± 0.5 | 8.9 ± 0.8a | 9.4 ± 0.7a | 12.3 ± 0.8a |
| Inflammatory factors | ||||
| TNF-α, pg/ml | 1.7 ± 0.1 | 1.8 ± 0.1 | 1.6 ± 0.1 | 1.4 ± 0.1a |
| IL-6, pg/ml | 2.8 ± 0.4 | 2.3 ± 0.3a | 1.7 ± 0.1a | 0.97 ± 0.1a |
| hsCRP, mg/dl | 1.4 ± 0.2 | 0.7 ± 0.1a | 0.4 ± 0.1a | 0.2 ± 0.1a |
| Orosomucoid, g/l | 1.01 ± 0.03 | 0.9 ± 0.04 | 0.8 ± 0.03a | 0.7 ± 0.03a |
a
p value < 0.05 versus basal (T0).