Table 5.
Genotype phenotype association results in the replication stage (significant results are shown in italics)
| Population and phenotype | CST3 rs2424577 |
||||
|---|---|---|---|---|---|
| A/A vs. A/G | A/A vs. G/G | A/G vs. G/G | A/A and A/G vs. G/G (dominant) | A/A vs. A/G and G/G (recessive) | |
| Danish men (lean) BMI | |||||
| p | 0.010 | 0.022 | 0.670 | 0.181 | 0.004 |
| estimate | −0.510 | −0.621 | 0.111 | −0.332 | −0.537 |
| 95% CI lower | −0.895 | −1.153 | −0.402 | −0.819 | −0.901 |
| 95% CI upper | −0.125 | −0.089 | 0.624 | 0.155 | −0.173 |
| Danish men (lean) waist circumference | |||||
| p | 0.027 | 0.040 | 0.634 | 0.211 | 0.012 |
| estimate | −1.784 | −2.298 | 0.515 | −1.283 | −1.907 |
| 95% CI lower | −0.206 | −0.100 | 2.633 | 0.729 | −0.413 |
| 95% CI upper | −3.361 | −4.497 | −1.604 | −3.294 | −3.400 |
| Danish men (lean) waist to hip ratio | |||||
| p | 0.025 | 0.027 | 0.535 | 0.158 | 0.010 |
| estimate | −0.011 | −0.015 | 0.004 | −0.009 | −0.012 |
| 95% CI lower | −0.001 | −0.002 | 0.017 | 0.003 | −0.003 |
| 95% CI upper | −0.021 | −0.028 | −0.009 | −0.021 | −0.021 |
| Danish men (obese) BMI | |||||
| p | 0.355 | 0.655 | 0.260 | 0.370 | 0.534 |
| estimate | 0.263 | −0.186 | 0.449 | −0.341 | 0.169 |
| 95% CI lower | 0.822 | 0.631 | 1.231 | 0.406 | 0.703 |
| 95% CI upper | −0.295 | −1.003 | −0.333 | −1.089 | −0.365 |
| Danish men (obese) waist circumference | |||||
| p | 0.635 | 0.605 | 0.377 | 0.435 | 0.820 |
| estimate | 0.561 | −0.895 | 1.456 | −1.230 | 0.258 |
| 95% CI lower | 2.886 | 2.497 | 4.691 | 1.864 | 2.482 |
| 95% CI upper | −1.763 | −4.286 | −1.779 | −4.323 | −1.966 |
| Danish men (obese) waist/hip ratio | |||||
| p | 0.946 | 0.461 | 0.411 | 0.401 | 0.860 |
| estimate | 0.000 | −0.007 | 0.007 | −0.007 | −0.001 |
| 95% CI lower | 0.013 | 0.012 | 0.025 | 0.010 | 0.011 |
| 95% CI upper | −0.012 | −0.026 | −0.010 | −0.024 | −0.013 |
| Swedish women BMI | |||||
| p | 0.297 | 0.019 | 0.090 | 0.027 | 0.165 |
| estimate | 0.143 | 0.846 | −0.704 | 0.766 | 0.293 |
| 95% CI lower | −0.350 | 0.119 | −1.409 | 0.094 | −0.178 |
| 95% CI upper | 0.636 | 1.574 | 0.002 | 1.437 | 0.763 |
| Swedish women waist circumference | |||||
| p | 0.514 | 0.131 | 0.046 | 0.058 | 0.945 |
| estimate | −0.623 | 2.186 | −2.808 | 2.540 | −0.063 |
| 95% CI lower | −2.495 | −0.654 | −5.562 | −0.091 | −1.857 |
| 95% CI upper | 1.250 | 5.025 | −0.055 | 5.171 | 1.732 |
| Swedish women waist to hip ratio | |||||
| p | 0.164 | 0.363 | 0.993 | 0.676 | 0.146 |
| estimate | −0.008 | −0.008 | 0.000 | −0.003 | −0.008 |
| 95% CI lower | −0.020 | −0.025 | −0.024 | −0.020 | −0.019 |
| 95% CI upper | 0.003 | 0.009 | −0.017 | 0.013 | 0.003 |
| Danish women (DNBC lean) BMI | |||||
| p | 0.425 | 0.989 | 0.537 | 0.711 | 0.532 |
| estimate | 0.117 | 0.003 | 0.114 | −0.064 | 0.086 |
| 95% CI lower | −0.171 | −0.376 | −0.248 | −0.405 | −0.184 |
| 95% CI upper | 0.404 | 0.382 | 0.476 | 0.276 | 0.357 |
| Danish women (DNBC lean) waist circumference | |||||
| P | 0.957 | 0.900 | 0.863 | 0.870 | 0.995 |
| estimate | −0.032 | 0.097 | −0.129 | 0.115 | 0.003 |
| 95% CI lower | −1.190 | −1.425 | −1.595 | −1.260 | −1.083 |
| 95% CI upper | 1.126 | 1.619 | 1.337 | 1.490 | 1.089 |
| Danish women (DNBC obese) BMI | |||||
| p | 0.666 | 0.413 | 0.236 | 0.270 | 0.961 |
| estimate | 0.078 | −0.202 | 0.280 | −0.247 | 0.008 |
| 95% CI lower | −0.277 | −0.686 | −0.184 | −0.686 | −0.328 |
| 95% CI upper | 0.434 | 0.282 | 0.744 | 0.192 | 0.345 |
| Danish women (DNBC obese) waist | circumference | ||||
| p | 0.994 | 0.140 | 0.025 | 0.040 | 0.908 |
| estimate | 0.893 | −1.914 | 2.807 | −2.411 | 0.107 |
| 95% CI lower | −1.058 | −4.455 | 0.353 | −4.708 | −1.723 |
| 95% CI upper | 2.845 | 0.628 | 5.262 | −0.114 | 1.937 |