Figure 1.

Workflow and summary of the results of the colocalization analysis of emphysema distribution–associated genetic variants with expression quantitative trait loci (eQTL) and epigenomic data. ACVR1B = activin A receptor type 1B; DCBLD1 = discoidin, CUB and LCCL domain containing 1; GWAS = genome-wide association studies; HBE = human bronchial epithelial; IGHV3 = immunoglobulin heavy variable 3; MEI1 = meiotic double-stranded break formation protein 1; PICS = probabilistic identification of causal SNPs.