Table 1.
Patient Characteristics
| Eosinophilic | Neutrophilic | Paucigranulocytic | |
|---|---|---|---|
| Number | 5 | 4 | 5 |
| Age (± SEM) | 11.2 ± 1.4 | 4.5 ± 1.8 | 8.3 ± 2.1 |
| Male sex, n (%) | 3 (60%) | 3 (75%) | 3 (60%) |
| Present atopy, n (%) | 4 (80%) | 2 (50%) | 2 (40%) |
| Eosinophils (%) | 4 ± 1 | 0 ± 0 | 0 ± 0 |
| PMNs (%) | 2 ± 1 | 34 ± 5 | 1 ± 1 |
| Mononuclear phagocytes (%) | 69 ± 6 | 54 ± 2 | 71 ± 10 |
| Serum IgE (median [25th–75th percentile]) | 330 (63–1,662) | 101 (18–288) | 30 (12–894) |
| AEC (median [25th–75th percentile]) | 593 (415–768) | 355 (115–835) | 180 (100–215) |
| ACT (mean ± SEM) | 13.2 ± 1.7 | 20.0 ± 3.5 | 15 ± 1.5 |
| ICU admission history (n) | 3 | 0 | 2 |
| Daily prednisone use (n) | 3 | 0 | 1 |
| ICS (fluticasone equivalents μg/d; median [25th–75th percentile]) | 800 (160–800) | 330 (160–725) | 480 (160–890) |
| Pre-FEV1/FVC (± SEM) | 0.76 ± 0.05 | 0.89* | 0.81 ± 0.05 |
| Post-FEV1/FVC (± SEM) | 0.83 ± 0.05 | ND | 0.87 ± 0.03 |
Definition of abbreviations: AEC = absolute eosinophil count; ACT = asthma control test; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; ICS = inhaled corticosteroid; ND = not done; PMNs = polymorphonuclear leukocytes.
*
Only one subject was old enough to participate in spirometry.