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. 2019 Apr 2;19:70. doi: 10.1186/s12866-019-1443-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Therapeutic effects of A. baumannii phage Bϕ-R2096 in a mouse model of acute pneumonia caused by carbapenem-resistant A. baumannii YMC13/03/R2096 strain. The C57BL/6 mice were intranasally inoculated with phage, bacteria, or both (n = 6 mice per group). Group 1 (control): PBS + SM buffer treatment; Group 2: A. baumannii-only-treatment; Group 3: phage Bϕ-R2096-only-treatment; Groups 4–6: postinfection phage Bϕ-R2096-treatment (MOI 10, 1, 0.1) 30 min after A. baumannii infection. A second cyclophosphamide (CP) and first bacteria treatment was given on day 2 (black arrow). Log-rank (Mantel-Cox) test, ***p < 0.001, *p = 0.0236