Table 1.
Case- control study – overall and stratified by sex for the SNPs rs17782313 and rs12970134
| SNP | Group | Genotypes1 n (%) |
Alleles (%) |
Odds ratio (OR) (95% CI)2 | p value2 | |||
|---|---|---|---|---|---|---|---|---|
| rs17782313 | TT | TC | CC | T | C | |||
| total overweight and obese children and adolescents | 436 (49.5) | 356 (40.4) | 89 (10.1) | 69.7 | 30.3 | ORTC 1.40 (1.16–1.70) | 3 × 10−4 | |
| total underweight controls3 | 254 (58.5) | 156 (36.0) | 24 (5.5) | 76.5 | 23.5 | ORCC 1.96 (1.35–2.88) | ||
| female overweight and obese children and adolescents | 236 (50.3) | 192 (40.9) | 41 (8.8) | 70.8 | 29.2 | ORTC 1.32 (1.03–1.70) | 0.029 | |
| female underweight controls3 | 153 (58.2) | 95 (36.1) | 15 (5.7) | 76.2 | 23.8 | ORCC 1.74 (1.06–2.90) | ||
| male overweight and obese children and adolescents | 200 (48.5) | 164 (39.8) | 48 (11.7) | 68.4 | 31.6 | ORTC 1.50 (1.12–2.03) | 0.006 | |
| male underweight controls3 | 101 (59.0) | 61 (35.7) | 9 (5.3) | 76.9 | 23.1 | ORCC 2.25 (1.26–4.10) | ||
| rs12970134 | GG | GA | AA | G | A | |||
| total overweight and obese children and adolescents | 415 (47.0) | 364 (41.2) | 104 (11.8) | 67.6 | 32.4 | ORGA 1.28 (1.07–1.54) | 0.007 | |
| total underweight controls3 | 231 (53.3) | 170 (39.3) | 32 (7.4) | 73.0 | 27.0 | OR AA 1.64 (1.14–2.36) | ||
| female overweight and obese children and adolescents | 226 (47.9) | 195 (41.3) | 51 (10.8) | 68.5 | 31.5 | ORGA 1.27 (1.00–1.62) | 0.052 | |
| female underweight controls3 | 142 (54.0) | 103 (39.2) | 18 (6.8) | 73.6 | 26.4 | OR AA 1.61 (1.00–2.63) | ||
| male overweight and obese children and adolescents | 189 (46.0) | 169 (41.1) | 53 (12.9) | 66.5 | 33.5 | ORGA 1.28 (0.97–1.69) | 0.086 | |
| male underweight controls3 | 89 (52.4) | 67 (39.4) | 14 (8.2) | 72.0 | 28.0 | ORAA 1.63 (0.94–2.87) | ||
1
In each genotype group the exact two-sided p-values for deviations from Hardy-Weinberg equilibrium were » 0.05.
2
Two-sided p value using the exact Cochran-Armitage trend test (assuming a linear trend).
3
The controls were a subsample from Hinney et al. [14] which was also genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0.