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. 2011 Feb 22;4(1):67–75. doi: 10.1159/000324557

Table 4.

Follow-up study in a subgroup of 367 overweight and obese children and adolescents (cases) – BMI-SDS at the beginning and after the intervention (BMI-SDS reduction) for genotypes at rs17782313 and rs12970134

SNP BMI-SDS1 Genotype n (%) Mean ± SD Estimate 95% CI p value2
Beginning of the intervention
rs17782313 all subjects CC 43 (11.72) 2.39 ± 0.46 0.044 −0.030 to 0.119 0.244
CT 149 (40.60) 2.45 ± 0.50
TT 175 (47.68) 2.36 ± 0.50
females CC 20 (9.76) 2.28 ± 0.49 0.009 −0.098 to 0.117 0.866
CT 87 (42.44) 2.45 ± 0.52
TT 98 (47.8) 2.36 ± 0.51
males CC 23 (14.2) 2.49 ± 0.43 0.079 −0.016 to 0.174 0.107
CT 62 (38.27) 2.45 ± 0.48
TT 77 (47.53) 2.36 ± 0.50
rs12970134 all subjects AA 52 (14.17) 2.39 ± 0.48 0.057 −0.015 to 0.129 0.124
AG 149 (40.60) 2.47 ± 0.51
GG 166 (45.23) 2.34 ± 0.49
females AA 27 (13.17) 2.27 ± 0.48 0.020 −0.081 to 0.122 0.695
AG 85 (41.46) 2.49 ± 0.53
GG 93 (45.37) 2.33 ± 0.50
males AA 52 (14.17) 2.39 ± 0.48 0.103 0.010–0.197 0.032
AG 149 (40.60) 2.47 ± 0.51
GG 166 (45.23) 2.34 ± 0.49
After the intervention (BMI-SDS reduction)
rs17782313 all subjects CC 43 (11.72) 0.29 ± 0.37 0.035 −0.014 to 0.084 0.163
CT 149 (40.60) 0.23 ± 0.35
TT 175 (47.68) 0.22 ± 0.30
females CC 20 (9.76) 0.44 ± 0.38 0.086 0.013–0.159 0.021
CT 87 (42.44) 0.21 ± 0.36
TT 98 (47.8) 0.19 ± 0.19
males CC 23 (14.2) 0.17 ± 0.31 −0.016 −0.079 to 0.046 0.547
CT 62 (38,271) 0.27 ± 0.33
TT 77 (47.53) 0.25 ± 0.24
rs12970134 all subjects AA 52 (14.17) 0.32 ± 0.38 0.039 −0.008 to 0.087 0.102
AG 149 (40.60) 0.22 ± 0.34
GG 166 (45.23) 0.22 ± 0.30
females AA 27 (13.17) 0.44 ± 0.39 0.092 0.024–0.160 0.009
AG 85 (41.46) 0.19 ± 0.35
GG 93 (45.37) 0.19 ± 0.34
males AA 25 (15.43) 0.20 ± 0.33 −0.019 −0.081 to 0.043 0.614
AG 64 (39.51) 0.24 ± 0.33
GG 73 (45.06) 0.26 ± 0.23
1

Effect of one copy of the minor (risk) allele in the additive genetic model as determined by linear regression adjusted for age (or age and sex in the analysis of both sexes) in the beginning of the intervention.

2

Positive values indicate relative weight reduction in units of BMI-SDS after the intervention.

3

Effect for one copy of the minor (risk) allele in the additive genetic model as determined by linear regression adjusted for age and BMI-SDS at the beginning of the intervention program (or age, BMI-SDS at the beginning of the intervention program and sex in the analysis of both sexes)

4

Two-sided p value.