Table 2.
Clinical Characteristics of all Patients with PH
| WHO Group 1 PAH |
WHO Group 2 PH | WHO Group 3 PH | ||
|---|---|---|---|---|
| Derivation Cohort | Validation Cohort | |||
| NYHA functional class, n (%)* | ||||
| Class I | 7 (9.9) | 3 (5.0) | 0 (0) | 3 (15) |
| Class II | 35 (49.3) | 26 (44.1) | 9 (60) | 6 (30) |
| Class III | 28 (39.4) | 26 (44.1) | 5 (33.3) | 11 (55) |
| Class IV | 1 (1.4) | 4 (6.8) | 1 (6.7) | 0 (0) |
| 6MWD, m, mean ± SEM (n)† | 440 ± 21 (35) | 379 ± 22 (50) | 395 ± 14 (3) | 324 ± 43 (9) |
| RHC measurements, mean ± SEM (n) | ||||
| RAP, mm Hg | 9 ± 1 (32) | 9 ± 1 (62) | 13 ± 2 (17) | 8 ± 1 (21) |
| mPAP, mm Hg | 49 ± 2 (42) | 48 ± 1 (62) | 43 ± 2 (19) | 33 ± 2 (21) |
| PCWP, mm Hg | 10 ± 1 (33) | 10 ± 0.4 (62) | 25 ± 1 (19) | 12 ± 1 (21) |
| CO, L/min | 5.0 ± 0.3 (40) | 4.5 ± 0.1 (62) | 5.7 ± 0.4 (18) | 5.4 ± 0.3 (21) |
| CI, L/min/m2 | 2.6 ± 0.1 (40) | 2.4 ± 0.1 (61) | 2.7 ± 0.2 (18) | 2.8 ± 0.2 (21) |
| PVR, Wood units | 8.8 ± 0.7 (41) | 9.6 ± 0.6 (62) | 3.6 ± 0.5 (18) | 4.4 ± 0.6 (21) |
| TTE RVSP, mm Hg, mean ± SEM (n)† | 72 ± 4 (47) | 70 ± 3 (46) | 68 ± 4 (16) | 61 ± 5 (13) |
| PAH therapy, n (%) | ||||
| Prostacyclin analogue | 24 (47.1) | N/A | 0 (0) | 0 |
| Endothelin antagonist | 21 (41.2) | N/A | 2 (14.3) | 2 (15.4) |
| PDE-5 inhibitor | 38 (74.5) | N/A | 5 (35.7) | 4 (30.8) |
Definition of abbreviations: 6MWD = 6-minute-walk distance; CI = cardiac index; CO = cardiac output; mPAP = mean pulmonary artery pressure; N/A = not available; NS = not significant (P > 0.05); NYHA = New York Heart Association; PAH = pulmonary arterial hypertension; PCWP = pulmonary capillary wedge pressure; PDE = phosphodiesterase; PH = pulmonary hypertension; PVR = pulmonary vascular resistance; RAP = right atrial pressure; RHC = right heart catheterization; RVSP = right ventricular systolic pressure; TTE = transthoracic echocardiogram; WHO = World Health Organization.
NS differences in distribution of each group versus derivation cohort, chi-square test.
NS differences versus derivation cohort, one-way ANOVA with Dunnett test for multiple comparisons.