Table 2.
Frequency of outcomes of interest by primaquine dose category
| No PQ | LDP | HDP | LDP or HDP versus no PQ | |
|---|---|---|---|---|
| n/N (%) | n/N (%) | n/N (%) | OR (95%CI) | |
| 1–6 m | ||||
| Severe anaemiaa | 10/246 (4.1) | 0/0 (–) | 0/0 (–) | – |
| Hb fall > 25% to < 5 g/dL | 4/183 (2.2) | 0/0 (–) | 0/0 (–) | – |
| Admission 3–30 d | 118/1208 (9.8) | 0/2 (0) | 0/13 (0) | – |
| Death 3–30 d | 11/1208 (0.91) | 0/2 (0) | 0/13 (0) | – |
| 6–12 m | ||||
| Severe anaemiaa | 21/451 (4.7) | 0/6 (0) | 5/27 (18.5) | 3.66 (1.28–10.4) |
| Hb fall > 25% to < 5 g/dL | 12/278 (4.3) | 0/4 (0) | 1/19 (5.3) | 1.01 (0.13–8.11) |
| Admission 3–30 d | 178/2224 (8.0) | 3/31 (9.7) | 9/161 (5.6) | 0.77 (0.42–1.40) |
| Death 3–30 d | 6/2224 (0.27) | 1/31 (3.2) | 2/161 (1.2) | 5.87 (1.46–23.6) |
| 1–12 m | ||||
| Severe anaemiaa | 31/697 (4.5) | 0/6 (0) | 5/27 (18.5) | 3.84 (1.39–10.6) |
| Hb fall > 25% to < 5 g/dL | 16/461 (3.5) | 0/4 (0) | 1/19 (5.3) | 1.26 (0.16–9.97) |
| Admission 3–30 d | 296/3432 (8.6) | 3/33 (9.1) | 9/174 (5.2) | 0.65 (0.36–1.18) |
| Death 3–30 d | 17/3432 (0.50) | 1/33 (3.0) | 2/174 (1.2) | 2.95 (0.86–10.2) |
PQ primaquine, LDP low dose primaquine, HDP high dose primaquine, n number with outcome, N denominator, OR odds ratio, 95% CI 95% confidence interval, Hb haemoglobin, m months, d day
aLimited to infants who were not severely anaemic at baseline