Table 2.

Derisking immune therapy.

I.	Baseline diagnostics
1. 2. 3. 4. 5. 6. (7.) (8.) (9.) (10.) (11.)	MRI FBC – leukocytes / platelets LFTs, U&E, urine, creatinine Pregnancy test Immunoglobulin levels Serum protein electrophoresis Infection serology a) HIV 1&2 b) Hepatitis B&C c) VZV d) Syphilis e) TB Elispot/Quantiferon assay Cervical smear Vaccinations LP (CSF analysis) Listeria prophylaxis
II.	Infusion-DMTs & IRTS
1. 2.	Infusion-related reactions a) Corticosteroids b) Antihistamines c) Antipyretics Infections a) Herpes prophylaxis b) Listeria/PJP prophylaxis
III.	Monitoring (general aspects, specific requirements depending on DMT)
1. 2. 3. 4. 5. 6. 7. 8.	Clinical disease activity MRI a) disease activity b) PML Blood a) FBC – leukopenia b) TFTs c) LFTs d) U&E, creatinine Urine a) Infection b) Renal dysfunction Infection a) Serology b) CSF (infection specific DNA, infection-specific ASI) Pregnancy (New) autoimmunity Malignancy surveillance and prevention (skin, cervical, breast, treatment of chronic hepatitis etc.)

ASI, antibody-specificity Index; CSF, cerebrospinal fluid; DMT, disease-modifying treatment;

DNA, deoxyribonucleic acid; FBC, full blood count; HIV, human immunodeficiency virus; IRTS, immune reconstitution therapies; LFT, liver function test; LP, lumbar puncture; MRI, magnetic resonance tomography; PJP, Pneumocystis jiroveci pneumonia; PML, progressive multifocal leukoencephalopathy; TB, tuberculosis; TFT, thyroid function test; U&E, urea & electrolytes; VZV, varicella zoster virus.