Table 4.
Per-patient-per-month all-cause healthcare costs by line of therapy stratified by patients with and without PN.
| Line of therapy |
|||
|---|---|---|---|
| First-line therapy |
|||
| PN in first line |
No PN first line |
p value | |
| n = 1267 | n = 2687 | ||
| Inpatient-admission costs, mean (SD) | $6158 ($18,095) | $5000 ($24,001) | 0.127 |
| Outpatient medical costs, mean (SD) | $12,598 ($11,306) | $10,949 ($11,319) | <0.001 |
| ER costs, mean (SD) | $180 ($798) | $129 ($766) | 0.055 |
| Outpatient office-visit costs, mean (SD) | $318 ($659) | $281 ($522) | 0.062 |
| Outpatient hospital-based visits, mean (SD) | $7687 ($10,244) | $6049 ($9927) | <0.001 |
| Laboratory-testing costs, mean (SD) | $212 ($552) | $197 ($454) | 0.376 |
| Outpatient prescription costs, mean (SD) | $4427 ($4103) | $4841 ($6715) | 0.043 |
| Total costs, mean (SD) | $23,183 ($22,243) | $20,790 ($27,748) | 0.007 |
| Second-line therapy |
|||
| PN second line |
No PN second line |
p value | |
| n = 280 | n = 1532 | ||
| Inpatient-admission costs, mean (SD) | $15,726 ($51,561) | $11,468 ($99,972) | 0.487 |
| Outpatient medical costs, mean (SD) | $15,807 ($22,951) | $11,277 ($18,854) | <0.001 |
| ER costs, mean (SD) | $271 ($2811) | $133 ($879) | 0.119 |
| Outpatient office-visit costs, mean (SD) | $244 ($325) | $240 ($483) | 0.889 |
| Outpatient hospital-based visits, mean (SD) | $11,250 ($21,747) | $7176 ($17,414) | 0.001 |
| Laboratory-testing costs, mean (SD) | $173 ($546) | $149 ($441) | 0.428 |
| Outpatient prescription costs, mean (SD) | $6348 ($6,192) | $6950 ($9282) | 0.297 |
| Total costs, mean (SD) | $37,880 ($58,007) | $29,694 ($103,457) | 0.198 |
| Third and subsequent lines of
therapy |
|||
| PN third+ line |
No PN third+ line |
p value | |
| n = 75 | n = 1028 | ||
| Inpatient-admission costs, mean (SD) | $7228 ($19,480) | $6488 ($27,591) | 0.820 |
| Outpatient medical costs, mean (SD) | $9803 ($12,438) | $10,563 ($15,657) | 0.681 |
| ER costs, mean (SD) | $148 ($347) | $126 ($784) | 0.812 |
| Outpatient office-visit costs, mean (SD) | $235 ($256) | $224 ($351) | 0.787 |
| Outpatient hospital-based visits, mean (SD) | $7414 ($11,805) | $6240 ($13,760) | 0.472 |
| Laboratory-testing costs, mean (SD) | $70 ($174) | $147 ($440) | 0.132 |
| Outpatient prescription costs, mean (SD) | $8563 ($7307) | $7777 ($11,021) | 0.543 |
| Total costs, mean (SD) | $25,594 ($26,656) | $24,827 ($34,532) | 0.851 |
ER, emergency department (room); PN, peripheral neuropathy; PPPM, per patient per month; SD, standard deviation.