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. 2019 Apr 1;10:2040620719839025. doi: 10.1177/2040620719839025

Table 4.

Per-patient-per-month all-cause healthcare costs by line of therapy stratified by patients with and without PN.

Line of therapy
First-line therapy
PN in first line
No PN first line
p value
n = 1267 n = 2687
Inpatient-admission costs, mean (SD) $6158 ($18,095) $5000 ($24,001) 0.127
Outpatient medical costs, mean (SD) $12,598 ($11,306) $10,949 ($11,319) <0.001
 ER costs, mean (SD) $180 ($798) $129 ($766) 0.055
 Outpatient office-visit costs, mean (SD) $318 ($659) $281 ($522) 0.062
 Outpatient hospital-based visits, mean (SD) $7687 ($10,244) $6049 ($9927) <0.001
 Laboratory-testing costs, mean (SD) $212 ($552) $197 ($454) 0.376
Outpatient prescription costs, mean (SD) $4427 ($4103) $4841 ($6715) 0.043
Total costs, mean (SD) $23,183 ($22,243) $20,790 ($27,748) 0.007
Second-line therapy
PN second line
No PN second line
p value
n = 280 n = 1532
Inpatient-admission costs, mean (SD) $15,726 ($51,561) $11,468 ($99,972) 0.487
Outpatient medical costs, mean (SD) $15,807 ($22,951) $11,277 ($18,854) <0.001
 ER costs, mean (SD) $271 ($2811) $133 ($879) 0.119
 Outpatient office-visit costs, mean (SD) $244 ($325) $240 ($483) 0.889
 Outpatient hospital-based visits, mean (SD) $11,250 ($21,747) $7176 ($17,414) 0.001
 Laboratory-testing costs, mean (SD) $173 ($546) $149 ($441) 0.428
Outpatient prescription costs, mean (SD) $6348 ($6,192) $6950 ($9282) 0.297
Total costs, mean (SD) $37,880 ($58,007) $29,694 ($103,457) 0.198
Third and subsequent lines of therapy
PN third+ line
No PN third+ line
p value
n = 75 n = 1028
Inpatient-admission costs, mean (SD) $7228 ($19,480) $6488 ($27,591) 0.820
Outpatient medical costs, mean (SD) $9803 ($12,438) $10,563 ($15,657) 0.681
 ER costs, mean (SD) $148 ($347) $126 ($784) 0.812
 Outpatient office-visit costs, mean (SD) $235 ($256) $224 ($351) 0.787
 Outpatient hospital-based visits, mean (SD) $7414 ($11,805) $6240 ($13,760) 0.472
 Laboratory-testing costs, mean (SD) $70 ($174) $147 ($440) 0.132
Outpatient prescription costs, mean (SD) $8563 ($7307) $7777 ($11,021) 0.543
Total costs, mean (SD) $25,594 ($26,656) $24,827 ($34,532) 0.851

ER, emergency department (room); PN, peripheral neuropathy; PPPM, per patient per month; SD, standard deviation.