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. 2019 Apr 1;10:2040620719839025. doi: 10.1177/2040620719839025

Table A.2.

Demographic and baseline clinical characteristics of first-line therapy.

Demographic characteristics First-line therapy
With PN
Without PN
p value
n = 1267
n = 2687
n/mean %/SD n/mean %/SD
Age (mean, SD) 64.0 10.81 64.2 11.61 0.661
Age group (n, %)
 18–34 4 0.3% 9 0.3% 1.000
 35–44 36 2.8% 95 3.5% 0.255
 45–54 204 16.1% 429 16.0% 0.914
 55–64 459 36.2% 1021 38.0% 0.283
 65–74 333 26.3% 555 20.7% 0.000
 75+ 231 18.2% 578 21.5% 0.017
Sex (n, %)
 Male 761 60.1% 1621 60.3% 0.874
 Female 506 39.9% 1066 39.7% 0.874
Payer (n, %)
 Commercial 690 54.5% 1536 57.2% 0.110
 Medicare 577 45.5% 1151 42.8% 0.110
Insurance plan type (n, %)
 Comprehensive 259 20.4% 503 18.7% 0.200
 Exclusive-provider organization 4 0.3% 19 0.7% 0.131
 Health-maintenance organization 141 11.1% 321 11.9% 0.455
 Point of service (POS) 66 5.2% 147 5.5% 0.734
 Preferred-provider organization 704 55.6% 1508 56.1% 0.742
 POS with capitation 8 0.6% 14 0.5% 0.663
 Consumer-driven healthplan 60 4.7% 116 4.3% 0.552
 High-deductible healthplan 25 2.0% 59 2.2% 0.651
 Unknown 0 0.0% 0 0.0%
Geographic region (n, %)
 Northeast 217 17.1% 488 18.2% 0.428
 North central 372 29.4% 744 27.7% 0.276
 South 448 35.4% 1011 37.6% 0.168
 West 221 17.4% 410 15.3% 0.080
 Unknown 9 0.7% 34 1.3% 0.116
Population density (n, %)
 Urban 1086 85.7% 2276 84.7% 0.406
 Rural 172 13.6% 379 14.1% 0.654
 Unknown 9 0.7% 32 1.2% 0.164
Duration of line of therapy (mean, SD) 234.9 219.9 244.6 241.2 0.222
DCI (mean, SD) 4.5 2.84 4.5 2.86 0.581
DCI (n, %)
 0 11 0.9% 21 0.8% 0.777
 1 12 0.9% 13 0.5% 0.086
 2 402 31.7% 900 33.5% 0.270
 3+ 842 66.5% 1753 65.2% 0.452
DCI components (n, %)
 Myocardial infarction 46 3.6% 87 3.2% 0.523
 Congestive heart failure 100 7.9% 217 8.1% 0.843
 Peripheral vascular disease 53 4.2% 112 4.2% 0.983
 Cerebrovascular disease 87 6.9% 179 6.7% 0.810
 Dementia 2 0.2% 7 0.3% 0.727
 Chronic pulmonary disease 206 16.3% 417 15.5% 0.551
 Rheumatologic disease 30 2.4% 60 2.2% 0.791
 Peptic ulcer disease 19 1.5% 50 1.9% 0.418
 Mild liver disease 10 0.8% 15 0.6% 0.392
 Diabetes (mild to moderate) 286 22.6% 561 20.9% 0.225
 Diabetes with chronic complications 93 7.3% 144 5.4% 0.014
 Hemiplegia or paraplegia 5 0.4% 11 0.4% 0.946
 Renal disease 285 22.5% 573 21.3% 0.405
 Moderate or severe liver disease 2 0.2% 5 0.2% 1.000
 Human immunodeficiency virus 3 0.2% 6 0.2% 1.000
 Any malignancy, including lymphoma and leukemia 1094 86.3% 2339 87.0% 0.542
 Metastatic solid tumor 190 15.0% 417 15.5% 0.670
Prior primary cancer (n, %)
 Solid tumor 309 24.4% 647 24.1% 0.832
 Hematologic cancer 157 12.4% 363 13.5% 0.332
Preperiod events of interest (n, %)
 Chronic kidney disease 243 19.2% 503 18.7% 0.730
 End-stage renal disease/renal failure 84 6.6% 170 6.3% 0.717
 Skeletal-related events 610 48.1% 1303 48.5% 0.838
 Hypercalcemia 172 13.6% 361 13.4% 0.904
 Venous thromboembolism 52 4.1% 120 4.5% 0.603
 Neutropenia 42 3.3% 93 3.5% 0.813
 Pneumonia 123 9.7% 251 9.3% 0.713
 Major bleeding 26 2.1% 52 1.9% 0.805
 GI bleeding 63 5.0% 141 5.2% 0.715
 Anemia 718 56.7% 1504 56.0% 0.681
 Anemia or anemia treatment 720 56.8% 1514 56.3% 0.776
 Thrombocytopenia 95 7.5% 188 7.0% 0.568
 Amyloidosis 49 3.9% 88 3.3% 0.342

DCI, Deyo–Charlson Comorbidity Index; GI, gastrointestinal; PN, peripheral neuropathy; SD, standard deviation.