Table A.4.
| Demographic characteristics | Third and subsequent line of
therapy |
||||
|---|---|---|---|---|---|
| With PN |
Without PN |
p value | |||
|
n = 75 |
n = 1028 |
||||
| n/mean | %/SD | n/mean | %/SD | ||
| Age (mean, SD) | 62.0 | 9.57 | 61.2 | 10.72 | 0.517 |
| Age group (n, %) | |||||
| 18–34 | 0 | 0.0% | 7 | 0.7% | |
| 35–44 | 2 | 2.7% | 44 | 4.3% | 0.764 |
| 45–54 | 14 | 18.7% | 227 | 22.1% | 0.490 |
| 55–64 | 31 | 41.3% | 408 | 39.7% | 0.779 |
| 65–74 | 19 | 25.3% | 210 | 20.4% | 0.312 |
| 75+ | 9 | 12.0% | 132 | 12.8% | 0.833 |
| Sex (n, %) | |||||
| Male | 50 | 66.7% | 617 | 60.0% | 0.256 |
| Female | 25 | 33.3% | 411 | 40.0% | 0.256 |
| Payer (n, %) | |||||
| Commercial | 45 | 60.0% | 671 | 65.3% | 0.356 |
| Medicare | 30 | 40.0% | 357 | 34.7% | 0.356 |
| Insurance plan type (n, %) | |||||
| Comprehensive | 11 | 14.7% | 176 | 17.1% | 0.585 |
| Exclusive-provider organization | 0 | 0.0% | 7 | 0.7% | |
| Health-maintenance organization | 9 | 12.0% | 130 | 12.6% | 0.871 |
| Point of service (POS) | 7 | 9.3% | 74 | 7.2% | 0.494 |
| Preferred-provider organization | 42 | 56.0% | 547 | 53.2% | 0.640 |
| POS with capitation | 0 | 0.0% | 5 | 0.5% | |
| Consumer-driven health plan | 4 | 5.3% | 66 | 6.4% | 1.000 |
| High-deductible health plan | 2 | 2.7% | 23 | 2.2% | 0.685 |
| Unknown | 0 | 0.0% | 0 | 0.0% | |
| Geographic region (n, %) | |||||
| Northeast | 11 | 14.7% | 188 | 18.3% | 0.431 |
| North central | 13 | 17.3% | 283 | 27.5% | 0.054 |
| South | 30 | 40.0% | 356 | 34.6% | 0.347 |
| West | 21 | 28.0% | 195 | 19.0% | 0.057 |
| Unknown | 0 | 0.0% | 6 | 0.6% | |
| Population density (n, %) | |||||
| Urban | 64 | 85.3% | 900 | 87.5% | 0.577 |
| Rural | 11 | 14.7% | 122 | 11.9% | 0.472 |
| Unknown | 0 | 0.0% | 6 | 0.6% | 0.507 |
| Duration of line of therapy (mean, SD) | 244.0 | 275.6 | 196.2 | 239.1 | 0.099 |
| DCI (mean, SD) | 4.3 | 2.84 | 4.0 | 2.55 | 0.274 |
| DCI (n, %) | |||||
| 0 | 0 | 0.0% | 15 | 1.5% | 0.292 |
| 1 | 0 | 0.0% | 0 | 0.0% | NA |
| 2 | 29 | 38.7% | 399 | 38.8% | 0.98 |
| 3+ | 46 | 61.3% | 614 | 59.7% | 0.784 |
| DCI components (n, %) | |||||
| Myocardial infarction | 0 | 0.0% | 16 | 1.6% | |
| Congestive heart failure | 2 | 2.7% | 32 | 3.1% | 1.000 |
| Peripheral vascular disease | 3 | 4.0% | 27 | 2.6% | 0.452 |
| Cerebrovascular disease | 6 | 8.0% | 66 | 6.4% | 0.625 |
| Dementia | 0 | 0.0% | 2 | 0.2% | |
| Chronic pulmonary disease | 12 | 16.0% | 150 | 14.6% | 0.739 |
| Rheumatologic disease | 2 | 2.7% | 13 | 1.3% | 0.272 |
| Peptic ulcer disease | 0 | 0.0% | 16 | 1.6% | |
| Mild liver disease | 3 | 4.0% | 4 | 0.4% | 0.009 |
| Diabetes (mild to moderate) | 13 | 17.3% | 210 | 20.4% | 0.519 |
| Diabetes with chronic complications | 2 | 2.7% | 54 | 5.3% | 0.581 |
| Hemiplegia or paraplegia | 1 | 1.3% | 1 | 0.1% | 0.131 |
| Renal disease | 14 | 18.7% | 218 | 21.2% | 0.602 |
| Moderate or severe liver disease | 0 | 0.0% | 2 | 0.2% | |
| Human immunodeficiency virus | 0 | 0.0% | 1 | 0.1% | |
| Any malignancy, including lymphoma and leukemia | 74 | 98.7% | 1000 | 97.3% | 0.716 |
| Metastatic solid tumor | 13 | 17.3% | 140 | 13.6% | 0.369 |
| Prior primary cancer (n, %) | |||||
| Solid tumor | 19 | 25.3% | 215 | 20.9% | 0.366 |
| Hematologic cancer | 11 | 14.7% | 125 | 12.2% | 0.524 |
| Preperiod events of interest (n, %) | |||||
| Chronic kidney disease | 11 | 14.7% | 168 | 16.3% | 0.704 |
| End-stage renal disease/renal failure | 2 | 2.7% | 48 | 4.7% | 0.573 |
| Skeletal-related events | 42 | 56.0% | 486 | 47.3% | 0.144 |
| Hypercalcemia | 10 | 13.3% | 115 | 11.2% | 0.571 |
| Venous thromboembolism | 1 | 1.3% | 38 | 3.7% | 0.512 |
| Neutropenia | 2 | 2.7% | 28 | 2.7% | 1.000 |
| Pneumonia | 5 | 6.7% | 84 | 8.2% | 0.644 |
| Major bleeding | 2 | 2.7% | 13 | 1.3% | 0.272 |
| GI bleeding | 3 | 4.0% | 46 | 4.5% | 1.000 |
| Anemia | 36 | 48.0% | 550 | 53.5% | 0.357 |
| Anemia or anemia treatment | 36 | 48.0% | 554 | 53.9% | 0.323 |
| Thrombocytopenia | 7 | 9.3% | 62 | 6.0% | 0.224 |
| Amyloidosis | 0 | 0.0% | 18 | 1.8% | 0.248 |
DCI, Deyo–Charlson Comorbidity Index; GI, gastrointestinal; NA, not applicaple; PN, peripheral neuropathy; SD, standard deviation.