Figure 3.

Kinetic survey of intestinal multi-drug resistant P. aeruginosa loads, following human or murine fecal microbiota transplantation in the infected secondary abiotic mice. Secondary abiotic mice were challenged with multi-drug resistant P. aeruginosa (Psae) on day (d) 0 and d1 by gavage and subjected to peroral fecal microbiota transplantation (FMT) from either human (closed circles) or murine donors (open circles) at d7, d8, and d9 postinfection (p.i.; i.e., D0, D+1 and D+2) or to PBS (mock, open diamonds). Immediately before and at defined time points (D) after the FMT, fecal samples were taken to assess intestinal P. aeruginosa loads by culture (expressed as colony forming units per gram, CFU/g). Medians, significance levels (p-values) determined by the Mann–Whitney U test, and the numbers of analyzed mice (in parentheses) are indicated. Data shown were pooled from 4 independent experiments