Figure 5.

Kinetic survey of intestinal multi-drug resistant P. aeruginosa loads, following murine fecal microbiota transplantation in the infected mice harboring a human gut microbiota. Mice with a human gut microbiota were challenged with multi-drug resistant P. aeruginosa (Psae) on day (d) 0 and d1 by gavage and subjected to peroral murine fecal microbiota transplantation (mFMT) at d7, d8, and d9 postinfection (as indicated by the arrows; i.e., D0, D+1, and D+2). Immediately before and at defined time points after the FMT, fecal samples were taken to assess intestinal P. aeruginosa loads by culture (expressed as colony forming units per gram, CFU/g). Medians, significance levels (p-values) determined by the Mann–Whitney U test, and the number of P. aeruginosa positive mice out of the total number of analyzed animals (in parentheses) are indicated. Data shown were pooled from 4 independent experiments