Table 1.
ARRIVE checklist for title (item number 1), abstract (item number 2), introduction (item number 3), objectives (item number 4), and methods (item number 5 and 6)
| Item | Number | Recommendation | Yes (%) | No (%) | 95% CI |
|---|---|---|---|---|---|
| Title | 1 | Provide as accurate and concise a description of the content of the article as possible | 161 (100) | 0 | |
| Abstract | 2 | Provide an accurate summary of the background, research objectives (including details of the species or strain of animal used), key methods, principal findings, and conclusions of the study | 161 (100) | 0 | 1 (0.97-1) |
| Introduction | |||||
| Background | 3 | (a) Include sufficient scientific background (including relevant references to previous work) to understand the motivation and context for the study, and explain the experimental approach and rationale | 161 (100) | 0 | 1 (0.97-1) |
| (b) Explain how and why the animal species and model being used can address the scientific objectives and, where appropriate, the study’s relevance to human biology | 33 (20.50) | 128 (79.50) | 0.20 (0.14-0.27) | ||
| Objectives | 4 | Clearly describe the primary and any secondary objectives of the study, or specific hypotheses being tested | 161 (100) | 0 | 1 (0.97-1) |
| Methods | |||||
| Ethical statement | 5 | Indicate the nature of the ethical review permissions, relevant licenses (e.g., animal [scientific procedures] act 1986), and national or institutional guidelines for the care and use of animals, that cover the research | 145 (90.06) | 16 (9.94) | 0.90 (0.84-0.93) |
| Study design | 6 | For each experiment, give brief details of the study design, including | |||
| (a) The number of experimental and control groups | 161 (100) | 0 | 1 (0.97-1) | ||
| (b) Any steps taken to minimize the effects of subjective bias when allocating animals to treatment (e.g., randomization procedure) | 73 (45.34) | 88 (54.66) | 0.45 (0.37-0.53) | ||
| (c) When assessing results (e.g., if done, describe who was blinded) | 18 (11.18) | 143 (88.82) | 0.11 (0.07-0.16) | ||
| (d) The experimental unit (e.g., a single animal, group, or cage of animals) A timeline diagram or flow chart can be useful to illustrate how complex study designs were carried out | 161 (100) | 0 | 1 (0.97-1) | ||
CI=Confidence interval