Table 2.
Item | Number | Recommendation | Yes (%) | No (%) | 95% CI |
---|---|---|---|---|---|
Methods | |||||
Experimental procedures | 7 | For each experiment and each experimental group, including controls, provide precise details of all procedures carried out. For example | |||
(a) How (e.g., drug formulation and dose, site and route of administration, anesthesia, and analgesia used [including monitoring], surgical procedure, method of euthanasia). Provide details of any specialist equipment used, including supplier (s) | 161 (100) | 0 | 1 (0.97-1) | ||
(b) When (e.g., time of day) | 12 (7.45) | 149 (92.55) | 0.07 (0.04-0.12) | ||
(c) Where (e.g., home cage, laboratory, and water maze) | 23 (14.29) | 138 (85.71) | 0.14 (0.09-0.20) | ||
(d) Why (e.g., rationale for choice of specific anesthetic, route of administration, and drug dose used) | 0 | 161 | - | ||
Experimental animals | 8 | (a) Provide details of the animals used, including species, strain, sex, developmental stage (e.g., mean or median age plus age range), and weight (e.g., mean or median weight plus weight range) | 153 (95.03) | 8 (4.97) | 0.95 (0.90-0.97) |
(b) Provide further relevant information such as the source of animals, international strain nomenclature, genetic modification status (e.g., knock-out or transgenic), genotype, health/immune status, drug or test naıve, previous procedures. | 158 (98.14) | 3 (1.86) | 0.98 (0.94-0.99) |
CI=Confidence interval