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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Sex Med. 2019 Jan 14;16(2):235–247. doi: 10.1016/j.jsxm.2018.12.007

Table 1.

Inclusion Criteria for SPRINT Participants. To be eligible, a screenee must have met criteria 1, 2, and 3.

General Inclusion Criteria for SPRINT

  1. Age ≥50 years

  2. Systolic Blood Pressure (SBP)

    SBP: 130-180 mmHg on 0 or 1 medication

    SBP: 130-170 mmHg on up to 2 medications

    SBP: 130-160 mmHg on up to 3 medications

    SBP: 130-150 mmHg on up to 4 medications

  3. At risk for CVD events based on at least one of the following:
    • (a)
      Presence of clinical or subclinical cardiovascular disease (CVD) other than stroke
      • (i)
        Clinical CVD (other than stroke)
        1. Previous myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass grafting (CaBg), carotid endarterectomy (CE), carotid stenting
        2. Peripheral artery disease (PAD) with revascularization
        3. Acute coronary syndrome with or without resting ECG change, ECG changes on a graded exercise test (GXT), or positive cardiac imaging study
        4. At least 50% diameter stenosis of a coronary, carotid, or lower extremity artery
        5. Abdominal aortic aneurysm (AAA) > 5 cm with or without repair
      • (ii)
        Subclinical CVD
        1. Coronary artery calcium score > 400 Agatston units within the past 2 years
        2. Ankle brachial index (ABI) <0.90 within the past 2 years
        3. Left ventricular hypertrophy (LVH) by ECG (based on computer reading) echocardiogram report, or other cardiac imaging procedure report within the past 2 years
    • (b)
      Chronic kidney disease, defined as estimated glomerular filtration rate 20 – 59 mL/min/1.732
    • (c)
      Framingham risk score for 10-year CVD risk >15% based on clinical features and laboratory results within the past 12 months
Targeted high-risk subgroup inclusion criteria
Chronic kidney disease: Qualifying chronic kidney disease was defined by estimated glomerular filtration rate, determined at baseline between 20 and 59 mL/min/1.73 m2, inclusive, based on the four-variable MDRD equation.
Senior: Participants who were at least 75 years old at the baseline visit.
CVD: Participants who met any of the inclusion criteria listed in 3a above at baseline.