Table 1.

17β-Estradiol Levels in Sham and CCI Male and Female Mice

17β-estradiol in pg/mL ± SEM
	Sham	1 dpi	3 dpi	7 dpi
Male	48.3 ± 6.2	53.4 ± 5.3	53.0 ± 2.4	42.8 ± 1.6
Female	72.3 ± 15.3	72.8 ± 13.8	64.7 ± 6.7	62.03 ± 12.2

17β-Estradiol was measured from serum of males and females sham and CCI across each time-point (n = 4 per group). Females mice had significantly higher 17β-estradiol levels compared with male mice (p < 0.05). Levels of 17β-estradiol in females were the same in the sham and CCI groups across each time-point, indicating no injury effect on plasma 17β-estradiol levels (p > 0.05). 17β-estradiol levels are expressed in pg/mL (mean ± SEM).

CCI, controlled cortical impact; SEM, standard error of the mean; dpi, days post-injury.