The mean skeletonized fractional anisotropy of all 47 subjects is overlaid on MNI-152 brain map in green color. Those white matter tracts with significantly lower ED in children with ASD compared with TDC are filled with red, based on voxel-wise TBSS analysis and after applying TFCE correction. ASD, autism spectrum disorder; ED, edge density; TBSS, tract-based spatial statistics; TDC, typically developing children; TFCE, threshold-free cluster enhancement. Color images are available online.