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. 2019 Mar 14;9(2):209–220. doi: 10.1089/brain.2018.0658

Table 2.

Univariate Comparison of DTI Microstructural and Connectome Metrics Between Select White Matter Tracts

  Edge density    
a ASD TDC t-test (p) Cohen's d
Splenium of corpus callosum 98,064 ± 38,508 120,153 ± 27,940 0.067 −0.62
Body of corpus callosum 67,818 ± 28,892 83,668 ± 16,510 0.072 −0.61
Genu of corpus callosum 53,289 ± 19,884 62,095 ± 19,969 0.178 −0.44
Left cingulate gyrus 57,579 ± 21,190 65,918 ± 13,110 0.190 −0.43
Right cingulate gyrus 56,360 ± 18,261 63,704 ± 13,393 0.190 −0.43
Left fornix 30,340 ± 20,081 24,397 ± 9,107 0.305 0.34
Right fornix 4,340 ± 3,844 7,427 ± 8,530 0.094 −0.55
Left medial lemniscus 8,975 ± 6,520 6,551 ± 4,193 0.216 0.41
Right medial lemniscus 6,994 ± 4,648 9,070 ± 4,381 0.168 −0.45
Left superior longitudinal fasciculus 87,892 ± 24,300 100,197 ± 16,483 0.100 −0.55
Right superior longitudinal fasciculus 89,976 ± 29,152 93,908 ± 17,252 0.644 −0.15
Left superior corona radiata 51,781 ± 15,441 56,318 ± 8,407 0.315 −0.33
Right superior corona radiata 51,440 ± 18,157 58,002 ± 11,306 0.227 −0.40
Left posterior corona radiata 76,082 ± 23,974 90,637 ± 16,416 0.052 −0.66
Right posterior corona radiata 76,488 ± 27,227 83,469 ± 14,360 0.378 −0.29
Left sagittal stratum 81,545 ± 23,179 85,438 ± 15,748 0.573 −0.18
Right sagittal stratum 79,984 ± 15,392 82,581 ± 16,006 0.606 −0.17
Left superior cerebellar peduncle 2,630 ± 2,407 1,811 ± 1,817 0.267 0.36
Left superior cerebellar peduncle 2,945 ± 2,426 4,362 ± 2,142 0.071 −0.60
Left tapetum 35,561 ± 13,204 43,427 ± 16,420 0.093 −0.55
Right tapetum 44,099 ± 19,023 48,948 ± 14,266 0.402 −0.27
  Fractional anisotropy    
b ASD TDC t-test (p) Cohen's d
Splenium of corpus callosum 0.655 ± 0.062 0.643 ± 0.020 0.494 0.22
Body of corpus callosum 0.578 ± 0.083 0.563 ± 0.031 0.521 0.21
Genu of corpus callosum 0.607 ± 0.068 0.591 ± 0.031 0.403 0.27
Left cingulate gyrus 0.401 ± 0.093 0.386 ± 0.034 0.556 0.19
Right cingulate gyrus 0.400 ± 0.096 0.373 ± 0.031 0.336 0.32
Left fornix 0.455 ± 0.087 0.441 ± 0.028 0.568 0.19
Right fornix 0.338 ± 0.093 0.358 ± 0.044 0.455 −0.24
Left medial lemniscus 0.547 ± 0.100 0.522 ± 0.029 0.377 0.29
Right medial lemniscus 0.538 ± 0.083 0.523 ± 0.027 0.513 0.21
Left superior longitudinal fasciculus 0.426 ± 0.079 0.416 ± 0.016 0.647 0.15
Right superior longitudinal fasciculus 0.433 ± 0.088 0.426 ± 0.014 0.757 0.10
Left superior corona radiata 0.464 ± 0.071 0.443 ± 0.015 0.291 0.35
Right superior corona radiata 0.453 ± 0.092 0.433 ± 0.017 0.431 0.26
Left posterior corona radiata 0.438 ± 0.066 0.417 ± 0.024 0.273 0.36
Right posterior corona radiata 0.430 ± 0.075 0.424 ± 0.023 0.764 0.10
Left sagittal stratum 0.446 ± 0.066 0.437 ± 0.023 0.621 0.16
Right sagittal stratum 0.434 ± 0.051 0.429 ± 0.025 0.770 0.09
Left superior cerebellar peduncle 0.570 ± 0.068 0.564 ± 0.042 0.745 0.10
Left superior cerebellar peduncle 0.553 ± 0.076 0.542 ± 0.036 0.629 0.16
Left tapetum 0.466 ± 0.083 0.441 ± 0.036 0.295 0.34
Right tapetum 0.482 ± 0.063 0.483 ± 0.035 0.953 −0.02
  Mean diffusivity (× 1,000)    
c ASD TDC t-test (p) Cohen's d
Splenium of corpus callosum 0.622 ± 0.025 0.625 ± 0.021 0.726 −0.11
Body of corpus callosum 0.672 ± 0.035 0.675 ± 0.029 0.786 −0.09
Genu of corpus callosum 0.615 ± 0.036 0.621 ± 0.035 0.604 −0.17
Left cingulate gyrus 0.724 ± 0.033 0.707 ± 0.036 0.131 0.50
Right cingulate gyrus 0.701 ± 0.034 0.706 ± 0.042 0.668 −0.14
Left fornix 0.682 ± 0.068 0.677 ± 0.027 0.791 0.09
Right fornix 1.070 ± 0.261 1.008 ± 0.116 0.406 0.27
Left medial lemniscus 0.627 ± 0.056 0.642 ± 0.020 0.359 −0.30
Right medial lemniscus 0.619 ± 0.036 0.625 ± 0.020 0.534 −0.20
Left superior longitudinal fasciculus 0.635 ± 0.024 0.630 ± 0.024 0.496 0.22
Right superior longitudinal fasciculus 0.641 ± 0.032 0.647 ± 0.026 0.536 −0.20
Left superior corona radiata 0.621 ± 0.025 0.617 ± 0.019 0.560 0.19
Right superior corona radiata 0.618 ± 0.022 0.612 ± 0.019 0.384 0.28
Left posterior corona radiata 0.680 ± 0.030 0.678 ± 0.028 0.793 0.08
Right posterior corona radiata 0.682 ± 0.038 0.684 ± 0.029 0.840 −0.07
Left sagittal stratum 0.678 ± 0.029 0.668 ± 0.026 0.273 0.36
Right sagittal stratum 0.694 ± 0.033 0.684 ± 0.027 0.338 0.31
Left superior cerebellar peduncle 0.681 ± 0.034 0.679 ± 0.034 0.800 0.08
Left superior cerebellar peduncle 0.672 ± 0.030 0.669 ± 0.024 0.807 0.08
Left tapetum 0.754 ± 0.055 0.731 ± 0.034 0.156 0.47
Right tapetum 0.737 ± 0.043 0.720 ± 0.036 0.196 0.43
  Radial diffusivity (× 1,000)    
d ASD TDC t-test (p) Cohen's d
Splenium of corpus callosum 0.342 ± 0.068 0.356 ± 0.023 0.479 −0.23
Body of corpus callosum 0.415 ± 0.078 0.429 ± 0.035 0.544 −0.20
Genu of corpus callosum 0.368 ± 0.059 0.383 ± 0.036 0.384 −0.28
Left cingulate gyrus 0.555 ± 0.073 0.551 ± 0.038 0.853 0.06
Right cingulate gyrus 0.539 ± 0.076 0.557 ± 0.044 0.401 −0.27
Left fornix 0.502 ± 0.091 0.502 ± 0.029 0.997 0.00
Right fornix 0.877 ± 0.270 0.809 ± 0.119 0.378 0.29
Left medial lemniscus 0.411 ± 0.083 0.432 ± 0.019 0.355 −0.30
Right medial lemniscus 0.410 ± 0.054 0.420 ± 0.021 0.525 −0.21
Left superior longitudinal fasciculus 0.481 ± 0.056 0.483 ± 0.024 0.875 −0.05
Right superior longitudinal fasciculus 0.483 ± 0.064 0.492 ± 0.025 0.606 −0.17
Left superior corona radiata 0.448 ± 0.043 0.456 ± 0.018 0.529 −0.20
Right superior corona radiata 0.449 ± 0.058 0.456 ± 0.017 0.672 −0.14
Left posterior corona radiata 0.504 ± 0.045 0.514 ± 0.031 0.482 −0.23
Right posterior corona radiata 0.511 ± 0.059 0.516 ± 0.031 0.765 −0.10
Left sagittal stratum 0.502 ± 0.040 0.499 ± 0.027 0.845 0.06
Right sagittal stratum 0.522 ± 0.036 0.517 ± 0.030 0.668 0.14
Left superior cerebellar peduncle 0.440 ± 0.050 0.438 ± 0.041 0.867 0.05
Left superior cerebellar peduncle 0.442 ± 0.054 0.445 ± 0.029 0.879 −0.05
Left tapetum 0.542 ± 0.070 0.539 ± 0.036 0.892 0.04
Right tapetum 0.523 ± 0.052 0.510 ± 0.037 0.401 0.27

The average ± standard deviation of edge density (a), fractional anisotropy (b), mean diffusivity (c), and radial diffusivity (d) are reported for select white matter tracts in each study group. Cohen's d was calculated as a measure of effect size (0.2: small; 0.5: medium; 0.8: large). Notably, of 48 white matter tracts in ICBM-DTI-81 atlas, those pairs with the largest effect size and/or those with significant voxel-wise difference (Table 1) were included.

DTI, diffusion tensor imaging.