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. Author manuscript; available in PMC: 2019 Apr 2.
Published in final edited form as: J Am Chem Soc. 2019 Feb 21;141(9):4147–4153. doi: 10.1021/jacs.9b01077

Scheme 2.

Flexible Synthesis of Neuromodulatorsa,b

Scheme 2.

aHydroarylation was accomplished as in Table 1, and Boc deprotection was performed with acid. bHordenine synthesis was accomplished by reduction with LiAlH4.