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. Author manuscript; available in PMC: 2019 Apr 2.
Published in final edited form as: J Am Chem Soc. 2019 Feb 21;141(9):4147–4153. doi: 10.1021/jacs.9b01077

Table 1.

Photocatalytic Radical Hydroarylation of Vinyl Amine Derivatives: Substrate Scopea,b,c,d,e

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a

Reaction conditions: Iodoarene (1.0 mmol), olefin (2.5 mmol), PTH (5 mol %), CySH (5 mol %), sodium formate (3.0 mmol), 5% (v/v) H2O/ DMSO (10.0 mL), blue light, 16 h; isolated yields given.

b

The reactions to produce 14 and 29 were conducted on a 0.5 mmol scale (1-chloro-4-iodobenzene).

c

In the reactions to produce 15 and 20, N-1-naphthylphenothiazine (5 mol %) was used in place of PTH.

d

In the reaction to produce 20, olefin (1.0 mmol) was used as a limiting reagent with 5.0 mmol of 3-iodopyridine.

e

In the reactions to produce 22−25, corresponding heteroaryl bromide was used as the aryl substrate.