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. 2019 Mar 26;10:246. doi: 10.3389/fneur.2019.00246

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Copyright © 2019 Sandsmark, Bogoslovsky, Qu, Haber, Cota, Davis, Butman, Latour and Diaz-Arrastia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma expression of vWF and cFN following TBI. (A) Plasma vWF measured ≤48 h after injury and (B) >48 h after injury. Plasma vWF was highest in the TH group and was decreased in the TVI group compared to the MRI-negative group at both time points. (C) Plasma cFn measured ≤48 h after injury and (D) >48 h after injury. There were no differences between the 3 MRI groups at the early time point. cFN was significantly increased in the TVI group >48 h after injury. Mann-Whitney tests were used to compare means between groups. ****p ≤ 0.00001; **p ≤ 0.05; ^nsp ≥ 0.05 (non-significant).