Table 3.

Genes associated with canonical pathways and network in prostate cancer.

Molecules in canonical pathways	Ratio	Genes associated with canonical pathways
Aryl hydrocarbon receptor signaling	5.19	HSPB3, NFIX, GSTT1, ARNT, GSTZ1, CTSD, HSP90B1, JUN, SP1, NCOA2, ALDH1A3, MAPK3, NEDD8, TGFB2, AHR, GSTA3, SRC, MGST1, CYP1A1, NFIC, TYR, GSTM3, NQO1, APAF1, MAPK8, ALDH8A1, BAX, NCOA3, ALDH9A1, AHRR, ALDH1L2, ALDH1A2, IL1B, ALDH3B1, DCT, ALDH16A1, MCM7
Bone metamorphosis signaling	4.66	HMP15, NFATC3, TAB2, CSNK1A1, WNT16, IL18R1, IKBKG, ITGA3, MAPK3, WNT7B, DKK2, IRS2, GSK3B, NFKBIB, BIRC3, WNT5B, TNFRSF11B, SPP1, WNT9A, TCF3, IL33, IL1RN, DKK4, IL1RAPL1, TCF4, IL1RL1, BMP3, LRP6, WNT8B, WNT2, JUN, NFAT5, AKT3, ALPL, SRC, IFNG, IL1RAPL2, GRB2, WNT2B, ITGA2, MAPK8, TCF7L1,IL36B,TRAF2,CSF1,IL1B,BMP7,DKK1,TCF7L2,LRP1,WNT11,IL11
Wnt/GSK-3β signaling	4.61	HFNG, TCF4, IFNE, WNT9A, WNT2B, IFNB1, CSNK1A1, WNT16, IFNA4, TCF7L1, TCF3, IFNA14, WNT8B, NCOA3, WNT2, NCOA2, WNT7B, NCOA1, GSK3B, IFNK, WNT5B,WNT11,TCF7L2
Glucocorticoid receptor signaling	4.35	HSPA14, NFATC3, HSPA5, HSPA4, CXCL3, IKBKG, KRT13, BAG1, MAPK3, SUMO1, KRT79, MRAS, IRS2, NFKBIB, TAB1, KRT31, KRT78, MED14, NCOA3, TAF4B, TAF1, KRT27, TAF5, TAF4, IL1RN, KRT19, NCOA1, KRT24, KRT18, KRT15, KRT34, ARID1A, IL5, KRT76, JAK2, MAPK11, HSPA1L, HSP90B1, NFAT5, JUN, AR, NCOA2, TGFB2, AKT3, KRT74, KRT20, NOS2, STAT1, MAP2K1, GTF2H3, KRT14, IFNG, IL3, VCAM1, KRT25, GRB2, TAF5L, MAPK8, KRT5 KRT35, TRAF2, GTF2H4, GTF2E1, IL1B, KRT6A, NPPA, PTGS2, JAK3, ELK1, TAF15
Immunity cell signaling	4.15	HOCS1, SOCS3, TRAF3, NFATC3, TLR8, CSNK1A1, IL17RC, WNT16, IL18R1, VEGFA, IKBKG, MAPK3, WNT7B, MRAS, DKK2, ATF4, IRS2, GSK3B, LTBR, NFKBIB, WNT5B, TNFRSF11B, MIF, WNT9A, TCF3, ATF2, IL33, IL1RN, DKK4, IL1RAPL1, TCF4, IL1RL1, LRP6, CEBPZ, JAK2, IL17RA, WNT8B, WNT2, IRAK1, NLK, JUN, NFAT5, AKT3, NOS2, MAP2K1, SRC, VCAM1, IL1RAPL2, GRB2, CREB3L3, IL15, WNT2B, TCF7L1, IL36B, TLR4, TRAF2, CSF1, IL1B, DKK1, TCF7L2, LRP1, WNT11, IRAK4, IRAK2
Gas signaling	4.08	HTR5A, HTR4, ADCY4, RACK1, LHCGR, GNG13, GNB4, MAPK3, MRAS, ATF4, ADORA2B, ADCY8, MAP2K1, GNG4, SRC, HRH2, ADD2, ADCY3, CREB3L3, DRD5, GNG3, CRHR1, MC4R, GNG10, ATF2, AVPR2, ADD3, MC1R, ELK1
Hypoxia signaling	3.62	HBE2A, CREB3L3, NQO1, UBE2W, NOS3, UBE2O, UBE2L6, ARNT, ATF2, VEGFA, UBE2L3, IKBKG, HSP90B1, JUN, EDN1, SUMO1, UBE2G1, UBE2K, ATF4, UBE2E3, NFKBIB
iNOS signaling	3.62	HFNG, IFNGR1, JAK2, MAPK11, RAK1, LR4, IKBKG, JUN, JAK3, NOS2, STAT1, NFKBIB, IRAK4, TAB1, IRAK2