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. 2019 Apr 2;10:1499. doi: 10.1038/s41467-019-09480-8

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Heritability estimate, partitioning enrichments of heritability, and genetic correlation analyses using LD score regression. a SNP-based heritability for AUDIT-C and AUD in the three populations and sex-stratified samples adequate in size for the analysis. b Partitioned heritability enrichment of cell type groups for AUDIT-C and AUD. Ten cell types tested were corrected for multiple testing. The black dashed line is the cutoff for Bonferroni-corrected significance. The gray dashed line is the cutoff for FDR < 0.05. c Genetic correlations with other traits. Data from 714 publicly available datasets (221 published and 493 unpublished from UK Biobank) were tested and corrected for multiple comparisons. The significantly correlated traits presented are for published data. Black lines are the cutoff for Bonferroni-corrected significance, with asterisks showing traits significant after correction. The traits are grouped into different categories and sorted by the genetic correlations with AUDIT-C (upper panel) or AUD (lower panel). CNS central nervous system, ADHD attention deficit hyperactivity disorder, MDD major depressive disorder