Table 1.

Genome-wide significant associations for AUDIT-C in the trans-population meta-analysis

rsID	Chr:posa	A1/A2	Geneb	EAF	N	Z-score	P_EA	P_AA	P_LA	P_EAA	P_SAA	Effect	P_ meta
rs1260326	2:27730940	C/T	GCKR c	0.652	270,226	8.22	1.74 × 10−16	0.110	0.067	0.987	0.739	+++++	2.04 × 10−16
rs2683616	2:58035555	A/G	VRK2 d	0.624	211,399	6.22	1.80 × 10−9	NA	0.060	0.487	NA	+?+−?	4.95 × 10−10
rs12639940	4:39420981	A/G	KLB c	0.613	194,761	5.93	3.45 × 10−9	NA	NA	0.626	NA	+??+?	3.06 × 10−9
rs1229984	4:100239319	C/T	ADH1B c	0.970	272,358	24.56	4.83 × 10−102	1.31 × 10−19	4.40 × 10−16	9.05 × 10−3	NA	++++?	3.62 × 10−133
rs142783062	4:100270960	D/I	ADH1C c	0.345	271,444	9.82	2.04 × 10−14	4.75 × 10−7	4.90 × 10−4	0.019	0.779	+++++	9.50 × 10−23
rs13107325	4:103188709	C/T	SLC39A8 c	0.937	270,248	11.45	1.43 × 10−25	1.07 × 10−4	2.23 × 10−3	NA	NA	+++??	2.24 × 10−30
rs4423856	4:150984857	T/C	DCLK2 d	0.796	212,444	5.66	3.60 × 10−8	NA	0.289	0.574	0.144	+?+++	1.48 × 10−8
rs2961816	5:50443691	A/C	ISL1 d	0.683	260,828	5.74	1.24 × 10−7	0.021	0.641	0.932	0.137	+++++	9.75 × 10−9
rs4841132	8:9183596	A/G	PPP1R3B d	0.101	271,192	−5.51	2.75 × 10−6	6.59 × 10−3	0.226	NA	0.148	−−−?+	3.62 × 10−8
rs62033408	16:53827962	A/G	FTO c	0.678	270,067	9.08	2.20 × 10−15	4.78 × 10−5	0.229	0.177	0.027	+++++	1.11 × 10−19
rs9902512	17:47094274	C/G	IGF2BP1 c	0.664	207,229	−5.81	3.81 × 10−8	NA	0.055	0.782	NA	−?−−?	6.24 × 10−9
rs142997686	17:79419159	D/I	BAHCC1 c	0.384	211,314	5.84	1.77 × 10−9	NA	0.944	0.434	0.840	+?−+−	5.39 × 10−9
rs75723348	22:41420679	T/G	RBX1 d	0.736	269,785	5.71	2.97 × 10−7	0.063	0.072	0.536	0.579	+++++	1.11 × 10−8

The loci shown represent completely independent signals after conditioning analyses

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian American

^aHuman Genome hg19 assembly

^bGene nearest to the lead SNP

^cProtein-coding gene contains the lead SNP

^dProtein-coding gene nearest to the lead SNP