Table 2.

Genome-wide significant associations for AUD in the trans-population meta-analysis

rsID	Chr:posa	A1/A2	Geneb	EAF	N	Z-score	P_EA	P_AA	P_LA	P_EAA	P_SAA	Effect	P_ meta
rs1260326	2:27730940	C/T	GCKR c	0.651	271,763	7.33	1.44 × 10−16	0.679	0.778	0.830	0.820	+++−+	2.27 × 10−13
rs540606	2:45138507	A/G	SIX3 d	0.409	213,336	−6.49	2.84 × 10−10	NA	0.175	0.411	NA	−?−−?	8.58 × 10−11
rs5860563	4:100047157	D/I	ADH4 c	0.723	271,487	−6.09	7.63 × 10−5	9.85 × 10−7	0.035	NA	0.412	−−−?+	1.12 × 10−9
rs1229984	4:100239319	C/T	ADH1B c	0.969	273,904	19.54	4.51 × 10−74	4.18 × 10−5	5.81 × 10−17	0.032	NA	++++?	4.68 × 10−85
rs1612735	4:100258007	T/C	ADH1C c	0.656	271,471	−8.86	1.75 × 10−14	6.42 × 10−5	0.022	0.938	0.054	−−−++	7.90 × 10−19
rs13107325	4:103188709	C/T	SLC39A8 c	0.937	271,784	7.60	2.73 × 10−14	0.064	0.363	NA	NA	+++??	2.97 × 10−14
rs7906104	10:110497101	T/C		0.272	270,278	−5.92	3.15 × 10−7	8.72 × 10−3	0.357	0.195	0.106	−−−−−	3.17 × 10−9
rs61902812	11:113374420	A/C	DRD2 d	0.304	271,218	−5.58	4.99 × 10−6	0.025	0.015	0.220	0.931	−−−−−	2.44 × 10−8
rs4936277e	11:113431960	A/G	DRD2 d	0.599	274,128	7.44	2.85 × 10−11	0.073	4.36 × 10−4	0.200	0.357	+++++	1.01 × 10−13
rs1421085	16:53800954	T/C	FTO c	0.670	274,340	6.69	3.26 × 10−10	0.024	0.525	0.332	0.018	+++++	2.17 × 10−11

The loci shown represent completely independent signals after conditioning analyses

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian Americans

^aHuman Genome hg19 assembly

^bGene nearest to the lead SNP

^cProtein-coding gene contains the lead SNP

^dProtein-coding gene nearest to the lead SNP

^eDifferent signal than rs61902812