Table 2.
Summary of significant associations identified by multiple GWAS using a maximum of 268 modern breed genomes
| Position/region | P value | Gene/locus | Function | Associated phenotype in this study |
|---|---|---|---|---|
| chr1:42085782-42573240 | 2.31E-11 | ESR1 | Major mediator of estrogen action for bone mass/osteoporosis42 | Height (long legs) |
| chr3:55954929-56065637 | 1.62E-10 | ADAMTSL3 locus | Human, pig and cattle loan weight QTL33 | Bulky breeds |
| chr3:91269525 | 4.04E-23 | LCORL* | Transcription factor - body size35–38 | Height, weight18, life-span |
| chr4:39182836 | 8.93E-11 | STC2 | Glycoprotein hormone - body size | Height16,18 |
| chr4:66902902-67093815 | 7.51E-14 | GHR | Growth hormone - body size | Height16,18 |
| chr7:26603745-28240043 | 4.47E-11 | GORAB | Gene involved in bones morphology74 | Curl tail |
| chr7:43724293-43890274 | 1.26E-10 | SMAD2 | Transcription factor - body size | Height16,18 |
| chr9:27659585 | 3.03E-40 | CA10 | Enzyme associated with metabolic syndrome75 | Hairless |
| chr10:8070103 | 7.63E-24 | WIF1-MSRB3-lncRNA * | Multi-traits locus in dogs | Drop ears 7, 52 |
| chr10:8351907-8488300 | 1.17E-26 | HMGA2 | Transcription factor - body size | Height16,18, boldness7,52 |
| chr11:14030600 | 9.53E-15 | ZNF608 locus | Body mass QTL in pig/body mass index QTL in human30 | Weight, Bulky breed |
| chr11:18621251-18855024 | 2.39E-09 | CHSY3 | Associated with mechanical function in cartilage76 | Curl tail |
| chr12:33803314-35061155 | 4.91E-41 | RIMS1-KCNQ5 | Neurological genes (cognition/potassium channel in cochlea)47,48 | Large ears |
| chr13:8610419 | 1.06E-68 | RSPO2 | Fur length and furnishing gene | Furnishing14 |
| chr15:41221438 | 6.35E-27 | IGF1 | Growth hormone - body size | Height, weight13,16,18, life-span |
| chr17:37651314 | 3.16E-67 | FOXI3 | Hairless in dogs | Hairless77 |
| chr18:20447435 | 5.95E-16 | FGF4 retrotransposon | Chondrodysplasia | Height18 |
| chr19:38303408 | 2.17E-13 | R3HDM1* | Meat QTL in cattle31 | Weight, bulky breed |
| chr20:21786368-21869849 | 5.99E-29 | MITF | Coat color | White chest, white head29 |
| chr20:26692625 | 1.21E-13 | ADAMTS9-AS* | Human adiposity locus32 | Weight |
| chr24:31856245 | 1.27E-07 | R3HDML | Associated with psychotic illness in human patients78 | Aggressiveness |
| chr26:12796099-13004170 | 2.08E-11 | TBX3-MED13L-RNFT2 | Body size locus | Height, weight 18 , life-span |
| chr29:23802662 | 1.95E-10 | HNF4G* | Intramuscular fat deposition of beef cattle34 | Bulky breed |
| chr32:4476417 | 4.71E-20 | FGF5 | Length of fur | Length of fur14 |
| chr34:20097018-212633271 | 1.26E-11 | IGF2BP2 locus | Growth hormone - body size | Weight18 |
| chrX:82919525 | 3.79E-57 | ACSL4 | Enzyme associated with body mass | Weight, bulky breed17 |
| chrX:82310627-86057014 | 3.38E-13 | CFAX-locus 1 ( IRS4 ) | Body mass locus | Height, weight17, life-span |
| chrX:101732248-103320770 | 2.69E-15 | CFAX-locus 2 (IGSF1) | Body mass locus | Height, weight, muscled breeds17, life-span |
Bold indicates identification in this study, and asterisk denote previously unreported mutations
Region or exact positions are defined by variants passing the Bonferroni correction threshold (8.46)