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. 2019 Apr 2;9:5473. doi: 10.1038/s41598-019-41837-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trends observed with respect to biochemical test parameters monitored in the study participant cohort. Pattern of changes in biochemical test parameters:(a) calcium, (b) plasma glucoseand (c) triglyceride levels respectively. Given that the interval between various sampling time-points was not equally spaced, the x-axis in panels a-c of the figure includes additional (non-sampling) time-points (indicated by black-coloured font). The LOWESS function in ggplot ver. 2.0⁴¹ was employed for plotting the trend-lines based on available values of alpha-diversity.