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. 2019 Apr 2;9:5473. doi: 10.1038/s41598-019-41837-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Statistical comparison of individual biochemical test parameters (grouped by dosage type and study phase). Results of Mann-Whitney rank-sum test carried out between values obtained for an individual biochemical test (e.g. triglyceride). For each dosage type (D1, D2, D3, or P) the test was carried out between (i) Set of values obtained from study participants belonging to a dosage type in the basal phase (B) vs. corresponding values in the dosage phase (D), (ii) Set of values obtained from study participants belonging to a dosage type in the dosage phase (D) vs. all samples in the follow-up phase (F), and (iii) Set of values obtained from study participants belonging to a dosage type in the basal phase (B) vs. all samples in the follow-up phase (F).