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. 2019 Apr 2;9:5500. doi: 10.1038/s41598-019-41933-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of lung biopsy sites (upper vs. lower lobes) for (a) ROS-formation, (b) mtDNA encoded respiratory chain function, (c) mtDNA-encoded protein, (d) mtDNA mutations in those 17 ILD-patients in whom simultaneous biopsies were performed. Lines connect measurements from the same patient. Boxes represent the 25th, 50th and 75th percentiles; whiskers define the lowest and highest data point within 1.5 times the interquartile range.