Table 2.

Structure and inhibition data of hit compounds from Sigma (S) and Chembridge (C) libraries.

Compound	Structure	% Inhibition with 100 µM compound	IC50 (µM)*
C13		57.1 ± 4.7a 86.7 ± 1.8b	13.2 ± 2.5
S10		59.7 ± 3.8a 42.6 ± 3.4b	30.2 ± 6.8
C7		38.9 ± 5.5a 92.0 ± 0.3b	44.1 ± 4.6
C16		33.3 ± 4.8a 28.7 ± 7.4c	46.4 ± 3.3
S2		31.8 ± 4.8a 52.9 ± 4.1b	90.0 ± 24.4
C25		34.9 ± 5.1a 27.8 ± 14.0c	109.5 ± 15.4
S6		32.3 ± 4.3a 6.3 ± 5.1c	123.0 ± 22.7
C14		34.0 ± 5.0a 60.2 ± 6.5b	141.8 ± 14.8
S13		33.8 ± 12.1a 41.9 ± 8.2b	159.0 ± 27.7
C17		30.3 ± 1.7a 23.8 ± 20.0c	233.4 ± 28.1
S11		30.0 ± 6.0a 56.3 ± 2.3b	289.0 ± 60.9

^aFluorescence assay, ^bcolorimetric assay, ^cCasp6-C163A cleavage assay, ^*IC₅₀ values were determined using fluorescence assay.