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. 2019 Apr 2;9:5484. doi: 10.1038/s41598-019-40759-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of the expression of cluster 1 and cluster 2 splicing factors with breast cancer overall survival. Per patient, mean expression of all factors within one cluster was calculated. Based on this mean expression, the patient cohort was median-split in low and high expression of cluster 1 or 2 splicing factors and survival curves for overall survival, relapse-free survival and metastasis-free survival were generated.