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. 2019 Apr 2;9:5484. doi: 10.1038/s41598-019-40759-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enhancer-SF and Suppressor-SF expression levels are related to cancer progression in a wide variety of cancer types. (A) Hierarchical clustering (Euclidean distance, complete linkage) of Enhancer- and Suppressor-SF correlations in various cancer types. Red = highly positively correlated, green = highly negatively correlated. (B) Mean correlation of Suppressor- and Enhancer-SFs to the sister chromatid cohesion pathway in various cancer types. Here, for every SF, the correlation to the SCC pathway was calculated per patient, after which the mean patient correlation was calculated. (C) Hierarchical clustering (Euclidean distance, complete linkage) of PCs of Suppressor- and Enhancer-SFs to sister chromatid cohesion factors. (D) Per lung cancer patient, mean expression of all Suppressor- and Enhancer-SFs was calculated. Based on these expression levels, the patient cohort was median-split and overall and post-progression survival plots were generated²⁶.